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Etonitazepyne information


Etonitazepyne
Legal status
Legal status
  • BR: Class F1 (Prohibited narcotics)
  • DE: Anlage II (Authorized trade only, not prescriptible)
  • UK: Under Psychoactive Substances Act
  • US: Schedule I
Identifiers
IUPAC name
  • 2-[(4-Ethoxyphenyl)methyl]-5-nitro-1-(2-pyrrolidin-1-ylethyl)benzimidazole
CAS Number
  • 2785346-75-8
PubChem CID
  • 155804760
ChemSpider
  • 103835282
UNII
  • 8HY67JQ9ZH
KEGG
  • C22701
Chemical and physical data
FormulaC22H26N4O3
Molar mass394.475 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • [O-][N+](=O)c1cc2nc(Cc3ccc(OCC)cc3)n(CCN3CCCC3)c2cc1
InChI
  • InChI=1S/C22H26N4O3/c1-2-29-19-8-5-17(6-9-19)15-22-23-20-16-18(26(27)28)7-10-21(20)25(22)14-13-24-11-3-4-12-24/h5-10,16H,2-4,11-15H2,1H3
  • Key:LQZWZCJCEPUKCJ-UHFFFAOYSA-N

Etonitazepyne (N-pyrrolidino etonitazene) is a benzimidazole derivative with potent opioid effects which has been sold over the internet as a designer drug and linked to numerous cases of overdose.[1][2][3][4]

  1. ^ Blanckaert P, Balcaen M, Vanhee C, Risseeuw M, Canfyn M, Desmedt B, et al. (September 2021). "Analytical characterization of "etonitazepyne," a new pyrrolidinyl-containing 2-benzylbenzimidazole opioid sold online". Drug Testing and Analysis. 13 (9): 1627–1634. doi:10.1002/dta.3113. hdl:1854/LU-8737722. PMID 34145779. S2CID 235479893.
  2. ^ Krotulski AJ, Papsun DM, Walton SE, Logan BK (2021). New High Potency Synthetic Opioid N-Pyrrolidino Etonitazene (Etonitazepyne) Linked to Overdoses Across United States (PDF) (Report). U.S. Department of Justice.
  3. ^ Montanari E, Madeo G, Pichini S, Busardò FP, Carlier J (August 2022). "Acute Intoxications and Fatalities Associated With Benzimidazole Opioid (Nitazene Analog) Use: A Systematic Review". Therapeutic Drug Monitoring. 44 (4): 494–510. doi:10.1097/FTD.0000000000000970. PMID 35149665. S2CID 246776288.
  4. ^ Vandeputte MM, Krotulski AJ, Walther D, Glatfelter GC, Papsun D, Walton SE, et al. (June 2022). "Pharmacological evaluation and forensic case series of N-pyrrolidino etonitazene (etonitazepyne), a newly emerging 2-benzylbenzimidazole 'nitazene' synthetic opioid". Archives of Toxicology. 96 (6): 1845–1863. doi:10.1007/s00204-022-03276-4. hdl:1854/LU-01GS866C8Q94ZVNMPTG3CQCK3J. PMID 35477798. S2CID 248416539.

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it is believed to be slightly less potent than the ethoxy analogue etonitazepyne but still a potent opioid. Isotonitazene Isotonitazepyne Metonitazene...

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the DEA to be placed under legal control in the US in December 2021. Etonitazepyne Isotonitazene List of benzimidazole opioids Hunger A, Kebrle J, Rossi...

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Opioid

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Equianalgesic

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(INS) 3:1 45–60 minutes 12–24 hours 14-Cinnamoyloxycodeinone 177 77 µg Etonitazepyne 180-190 55-60 µg Protonitazepyne 180-190 55-60 µg Remifentanil 100–200...

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