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Histopathology of anal epithelium:[1] A. Normal histology, negative for anal intraepithelial neoplasia lesion (AIN) B. Low-grade dysplasia, here called low-grade squamous intraepithelial lesion (LSIL) C. High-grade dysplasia, here called high grade squamous intraepithelial lesion (HSIL) D. Squamous cell carcinoma, infiltrating the stroma (middle and left in image), and HSIL (right in image)
Epithelial dysplasia, a term becoming increasingly referred to as intraepithelial neoplasia, is the sum of various disturbances of epithelial proliferation and differentiation as seen microscopically. Individual cellular features of dysplasia are called epithelial atypia.[2]
Examples of epithelial dysplasia include cervical intraepithelial neoplasia – a disorder commonly detected by an abnormal pap smear) consisting of an increased population of immature (basal-like) cells which are restricted to the mucosal surface, and have not invaded through the basement membrane to the deeper soft tissues. Analogous conditions include vaginal intraepithelial neoplasia and vulvar intraepithelial neoplasia. Metanephric dysplastic hematoma of the sacral region is a dysplastic overgrowth observed in infants.
^Liu, Xuefeng; Rovelli, Cristina; Poli, Andrea; Galli, Laura; Cernuschi, Massimo; Tamburini, Andrea Marco; Racca, Sara; Tambussi, Giuseppe; Rolla, Serena; Albarello, Luca; Rosati, Riccardo; Lazzarin, Adriano; Castagna, Antonella; Nozza, Silvia (2017). "Presence of multiple genotypes in subjects with HPV-16 infection is highly associated with anal squamous intraepithelial lesions in HIV-1 infected males". PLOS ONE. 12 (10): e0186367. Bibcode:2017PLoSO..1286367R. doi:10.1371/journal.pone.0186367. ISSN 1932-6203. PMC 5663371. PMID 29088236.
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^"Epithelial dysplasia - definition of epithelial dysplasia by Medical dictionary". TheFreeDictionary.com. Retrieved 20 Dec 2016.
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