Epileptogenesis is the gradual process by which a typical brain develops epilepsy.[1] Epilepsy is a chronic condition in which seizures occur.[2] These changes to the brain occasionally cause neurons to fire in an abnormal, hypersynchronous manner, known as a seizure.[3]
^Lukasiuk, K. (2014). "Epileptogenesis". In Aminoff, Michael J; Daroff, Robert B (eds.). Encyclopedia of the Neurological Sciences (Second Edition). Vol. 2 (Second ed.). London: Academic Press. pp. 196–199. ISBN 978-0-12-385157-4.
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McNamara JO, Huang YZ, Leonard AS (October 2006). "Molecular signaling mechanisms underlying epileptogenesis". Sci. STKE. 2006 (356): re12. doi:10.1126/stke.3562006re12. PMID 17033045. S2CID 42882078.
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Armijo JA, Valdizán EM, De Las Cuevas I, Cuadrado A (2002). "Advances in the physiopathology of epileptogenesis: Molecular aspects". Rev Neurol (in Spanish). 34 (5): 409–29. PMID 12040510.
structural/metabolic, or unknown. Anything that causes epilepsy causes epileptogenesis, because epileptogenesis is the process of developing epilepsy. Structural causes...
infections of the brain, or birth defects through a process known as epileptogenesis. Known genetic mutations are directly linked to a small proportion...
The GAERS or Genetic Absence Epilepsy Rat from Strasbourg is a recognized animal model of absence epilepsy, a typical childhood form of epilepsy characterized...
circuits. These secondary epilepsies occur through processes known as epileptogenesis. Failure of the blood–brain barrier may also be a causal mechanism...
uncontrolled neuronal firing, leading to seizures. The secondary epileptogenesis hypothesis is that repetitive seizures lead to interneuron loss, loss...
molecular regulation of glutamate and GABA transporter proteins during epileptogenesis in rats with hippocampal seizures". Brain Research. Molecular Brain...
epilepsy. However, no drug has been shown in human trials to prevent epileptogenesis (the development of epilepsy in an individual at risk, such as after...
discoveries of the link between blood–brain barrier (BBB) disruption and Epileptogenesis (development of epilepsy) and the mechanisms underlying it, and for...
development of seizure susceptibility. The development of epilepsy (epileptogenesis) is a process that is poorly understood. A few anticonvulsants (valproate...
disease-modifying activity of progesterone in the hippocampus kindling model of epileptogenesis". Epilepsy & Behavior. 25 (1): 92–7. doi:10.1016/j.yebeh.2012.05.024...
understanding of how normal brains develop epilepsy (a process known as Epileptogenesis), and have been used in pre-clinical trials of antiepileptic drugs...
CA3 Pyramidal Cells: Mechanisms for Epileptic Synchronization and Epileptogenesis", in Schwartzkroin, Philip A. (ed.), Encyclopedia of Basic Epilepsy...
phenomenon led to his conclusion that kindling can be used to model human epileptogenesis, learning and memory. The publication of these results opened a completely...
1998). "The role of the ventromedial nucleus of the hypothalamus in epileptogenesis". NeuroReport. 9 (16): 3623–9. doi:10.1097/00001756-199811160-00013...
of GluK1 kainate receptors in seizures, epileptic discharges, and epileptogenesis". The Journal of Neuroscience. 34 (17): 5765–75. doi:10.1523/JNEUROSCI...
models. Deletion of either GluK1 or GluK2 does not alter kindling epileptogenesis or the expression of kindled seizures. Recent investigation through...
PMID 18504292. Stafstrom CE (2005). "The role of the subiculum in epilepsy and epileptogenesis". Epilepsy Curr. 5 (4): 121–9. doi:10.1111/j.1535-7511.2005.00049.x...
CA3 Pyramidal Cells: Mechanisms for Epileptic Synchronization and Epileptogenesis", in Schwartzkroin, Philip A. (ed.), Encyclopedia of Basic Epilepsy...
of GluK1 kainate receptors in seizures, epileptic discharges, and epileptogenesis". The Journal of Neuroscience. 34 (17): 5765–5775. doi:10.1523/JNEUROSCI...
(plasmalemma and nuclear envelope); molecular mechanisms of epilepsy and epileptogenesis and pharmacological agents with antiseizure properties; the role of...
and reflex epilepsies: old models for understanding mechanisms of epileptogenesis". Epilepsy Research. 100 (1–2): 1–11. doi:10.1016/j.eplepsyres.2012...
Scimemi, A.; Schorge, S; Kullmann, D. M.; Walker, M. C. (2005). "Epileptogenesis is Associated with Enhanced Glutamatergic Transmission in the Perforant...
seizures are triggered, potentially resulting in the development of epileptogenesis. Studies have shown that ADK overexpression results from astrogliosis...
involved in animal research studies dealing with stress influence on epileptogenesis He is the co-inventor of the “Epileptogenicity Index, a method for...
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