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Chemical compound
Echinocandin B, a lipopeptide, is a naturally occurring cyclic hexapeptide with a linoleoyl side chain. It belongs to a class of antifungal agents called echinocandins, which inhibits the synthesis of glucan, a major component of the fungal cell wall, via noncompetitive inhibition of a crucial enzyme, β-(1→3)-D-glucan synthase. Echinocandin B is a fermentation product of Aspergillus nidulans and the closely related species, A. rugulosus;[1] discovered in 1974 in A. nidulans var. echinulatus strain A 32204 in Germany,[2] it was the first of the echinocandin class of antifungals.
Echinocandin B can undergo deacylation (removal of the lipid side chain) by the action of a deacylase enzyme from the filamentous bacterium Actinoplanes utahensis, which catalyzes the cleavage of the linoleoyl side chain;[3] in three subsequent synthetic steps, including a chemical reacylation, the antifungal drug anidulafungin is synthesized.[4]
^Denning DW (1997). "Echinocandins and pneumocandins - a new antifungal class with a novel mode of action". J Antimicrob Chemother. 40 (5): 611–614. doi:10.1093/jac/dkf045. PMID 9421307.
^Nyfeler R, Keller-Schierlein W (1974). "Metabolites of microorganisms. 143. Echinocandin B, a novel polypeptide-antibiotic from Aspergillus nidulans var. echinulatus: isolation and structural components". Helv Chim Acta. 57 (8): 2459–2477. doi:10.1002/hlca.19740570818. PMID 4613708.
^Lei Shao; Jian Li; Aijuan Liu; Qing Chang; Huimin Lin; Daijie Chen (2013). "Efficient Bioconversion of Echinocandin B to Its Nucleus by Overexpression of Deacylase Genes in Different Host Strains". Applied and Environmental Microbiology. 79 (4): 1126–1133. Bibcode:2013ApEnM..79.1126S. doi:10.1128/AEM.02792-12. PMC 3568618. PMID 23220968.
^"Anidulafungin EMA Europa" (PDF). Archived from the original (PDF) on 2018-06-19.
Echinocandins are a class of antifungal drugs that inhibit the synthesis of β-glucan in the fungal cell wall via noncompetitive inhibition of the enzyme...
EchinocandinB, a lipopeptide, is a naturally occurring cyclic hexapeptide with a linoleoyl side chain. It belongs to a class of antifungal agents called...
ascospores. Anidulafungin is a semisynthetic lipopeptide antifungal drug of echinocandinB subclass, derived from a fermentation product of A. nidulans var. echinulatus...
Anidulafungin (INN): 42 (trade names Eraxis, Ecalta) is a semisynthetic echinocandin used as an antifungal drug. It was previously known as LY303366. It may...
acid, 6,7,8-trihydroxy-3-methylisocoumarin, desferritriacetylfusigen, echinocandinB, and sterigmatocystin. A. navahoensis has been cultivated on both Czapek...
Pneumocandin B0, also known as pneumocandin B0, pneumocandin B(0), and hydroxy echinocandin, is an organic chemical compound with the formula C50H80N8O17...
Papulacandin B is a papulacandin isolated from a strain of Papularia sphaerosperma. It is a molecule with antifungal activity. Echinocandin Traxler, P.;...
peripheral organs. For invasive disease, treatments include amphotericin B, echinocandins, or extended-spectrum triazole antifungals. In the history of fungi...
synthesis. Examples include butenafine, naftifine, and terbinafine. Echinocandins inhibit the creation of glucan in the fungal cell wall by inhibiting...
treatment is an echinocandin class antifungal (caspofungin, micafungin, or anidulafungin) given intravenously. Fluconazole, amphotericin B, and other antifungals...
Aminocandin is an echinocandin antifungal. It works by targeting the glucan in fungal cell walls. Andes D, Marchillo K, Lowther J, Bryskier A, Stamstad...
antifungal drugs of class echinocandins, recommended as the first method of treatment against invasive candidiasis. The three echinocandins currently licensed...
Cilofungin (INN) is the first clinically applied member of the echinocandin family of antifungal drugs. It was derived from a fungus in the genus Aspergillus...
structure to fluconazole) and caspofungin (glucan synthesis inhibitor of the echinocandin structural class). However, these drugs have not been FDA approved, and...
Merck & Co., Inc.. It is a member of a class of antifungals termed the echinocandins.[medical citation needed] It works by inhibiting the enzyme (1→3)-β-D-glucan...
important. They represent a drug target for antifungal medications of the echinocandin class. The following are glucans (The α- and β- and numbers clarify the...
widespread disease, an echinocandin such as caspofungin or micafungin is used. A number of weeks of intravenous amphotericin B may be used as an alternative...
in vivo, against multidrug-resistant pathogens, including azole- and echinocandin-resistant strains. Ibrexafungerp is a triterpenoid antifungal agent....
vs non-neutropenic candidemia is treated differently. An intravenous echinocandin such as anidulafungin, caspofungin or micafungin is recommended as first-line...
to 35% were reported resistant to amphotericin B; however, most isolates are susceptible to echinocandins. Treatment is complicated because C. auris is...
kudriavzevii can be successfully treated with voriconazole, amphotericin B, and echinocandins (micafungin, caspofungin, and anidulafungin).[citation needed] Cacao...
"New developments and directions in the clinical application of the echinocandins". Archives of Toxicology. 91 (4): 1613–1621. doi:10.1007/s00204-016-1916-3...
resistant to common treatments like fluconazole. N. glabratus resistance to Echinocandin is also increasing, leaving expensive and toxic antifungal treatments...
isolated from soil in Xinjiang in China. It has been reported to produce echinocandins. A. pachycristatus has been cultivated on both Czapek yeast extract...
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