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as acetate: CC(O)=O.CC(O)=O.[H][C@@]12C[C@@H](O)CN1C(=O)[C@@H](NC(=O)[C@]([H])(C[C@@H](O)[C@@H](NCCN)NC(=O)[C@@H]1[C@@H](O)CCN1C(=O)[C@@H](NC(=O)[C@@H](NC2=O)[C@H](O)[C@@H](O)C1=CC=C(O)C=C1)[C@H](O)CCN)NC(=O)CCCCCCCC[C@@H](C)C[C@@H](C)CC)[C@@H](C)O
as acetate: InChI=1S/C52H88N10O15.2C2H4O2/c1-5-28(2)24-29(3)12-10-8-6-7-9-11-13-39(69)56-34-26-38(68)46(55-22-21-54)60-50(75)43-37(67)19-23-61(43)52(77)41(36(66)18-20-53)58-49(74)42(45(71)44(70)31-14-16-32(64)17-15-31)59-48(73)35-25-33(65)27-62(35)51(76)40(30(4)63)57-47(34)72;2*1-2(3)4/h14-17,28-30,33-38,40-46,55,63-68,70-71H,5-13,18-27,53-54H2,1-4H3,(H,56,69)(H,57,72)(H,58,74)(H,59,73)(H,60,75);2*1H3,(H,3,4)/t28-,29+,30+,33+,34-,35-,36+,37-,38+,40-,41-,42-,43-,44-,45-,46-;;/m0../s1
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Caspofungin (INN;[1][4] brand name Cancidas) is a lipopeptide antifungal drug from Merck & Co., Inc..[5] It is a member of a class of antifungals termed the echinocandins.[medical citation needed] It works by inhibiting the enzyme (1→3)-β-D-glucan synthase and thereby disturbing the integrity of the fungal cell wall.[medical citation needed]
Caspofungin was the first inhibitor of fungal (1→3)-β-D-glucan synthesis to be approved by the United States Food and Drug Administration.[6] Caspofungin is administered intravenously.[2] It is on the World Health Organization's List of Essential Medicines.[7]
^ ab"International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary names (Rec.INN): List 42" (PDF). World Health Organization. 1999. Retrieved 11 November 2016.
^ abc"Cancidas- caspofungin acetate injection, powder, lyophilized, for solution". DailyMed. 20 November 2023. Retrieved 20 March 2024.
^"Prescription medicines: registration of new generic medicines and biosimilar medicines, 2017". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 30 March 2024.
^European Medicines Agency's list of authorised medicines for human use (C) Archived 17 October 2007 at the Wayback Machine
^"Patent Covering Caspofungin". Retrieved 18 March 2015.
^World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
Caspofungin (INN; brand name Cancidas) is a lipopeptide antifungal drug from Merck & Co., Inc.. It is a member of a class of antifungals termed the echinocandins...
cell wall components, the fungal equivalent to bacterial peptidoglycan. Caspofungin, micafungin, and anidulafungin are semisynthetic echinocandin derivatives...
was successful. Several case reports have studied caspofungin, with differing results. Caspofungin 50 mg/day following administration of amphotericin...
pathogenic fungi such as Candida. This compound is used to synthesize caspofungin. Pneumocandin B0 can be easily confused with pneumocandin B, although...
clotrimazole. In those with widespread disease, an echinocandin such as caspofungin or micafungin is used. A number of weeks of intravenous amphotericin...
treated with voriconazole, amphotericin B, and echinocandins (micafungin, caspofungin, and anidulafungin).[citation needed] Cacao beans have to be fermented...
species. Griseofulvin is derived from a number of Penicillium species; caspofungin is derived from Glarea lozoyensis. Strobilurin, azoxystrobin, micafungin...
pulmonary aspergillosis and acute invasive aspergillosis. Anidulafungin and caspofungin are alternatives Valaciclovir is an alternative also indicated for pre-exposure...
echinocandins currently licensed for medical use, namely anidulafungin, caspofungin, and micafungin, are potent against candidiasis, which has grown resistant...
is chosen. If fungal infection is suspected, an echinocandin, such as caspofungin or micafungin, is chosen for people with severe sepsis, followed by triazole...
B and nystatin, along with variable vulnerability to flucytosine and caspofungin. However, intravenous amphotericin B is a medication of last resort,...
effective, allowing a lower dose. Other drugs used, such as amphotericin B, caspofungin (in combination therapy only), flucytosine (in combination therapy only)...
treated differently. An intravenous echinocandin such as anidulafungin, caspofungin or micafungin is recommended as first-line therapy for fungemia, specifically...
fumigatus which may be of benefit when used with other medications, such as caspofungin, ranconazole and amphotericin B, fluconazole or itraconazole. Nikkomycin...
antifungals, including amphotericin B, itraconazole, voriconazole, and caspofungin. Aspergillus lentulus is an opportunistic human pathogen that causes...
therapy treatment including 3 agents used; caspofungin, micafungin and anidulafungin. Usage of caspofungin will efficiently target against oropharyngeal...
M, Talwar D, De Waele JJ, et al. (October 2007). "Micafungin versus caspofungin for treatment of candidemia and other forms of invasive candidiasis"...
of Disseminated Geotrichum capitatum Infection with a Combination of Caspofungin and Voriconazole in an Immunocompromised Patient". Mycoses. 51 (3): 270–2...
most adults, the initial treatment is an echinocandin class antifungal (caspofungin, micafungin, or anidulafungin) given intravenously. Fluconazole, amphotericin...
such as amphotericin B, itraconazole, voriconazole, posaconazole, and caspofungin; however, some antifungal resistance has been shown in amphotericin B...
atorvastatin, rosiglitazone, pioglitazone, celecoxib, clarithromycin, caspofungin, voriconazole, and lorazepam. Rifampicin is antagonistic to the microbiologic...
acute invasive aspergillosis. Alternatives limited to anidulafungin and caspofungin for use in second-line regimens in accordance with WHO treatment guidelines...
antibiotics. Moenomycin is used in animal feed as a growth promoter. Caspofungin has been developed from the echinocandins and is in use as an antifungal...
however, four classes of drugs (itraconazole (a triazole), voriconazole, caspofungin and amphotericin B) demonstrate fungicidal effectiveness that is most...
activity of amphotericin B, itraconazole, voriconazole, posaconazole, caspofungin and terbinafine against Scytalidium dimidiatum and Scytalidium hyalinum...
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