Echinoderm microtubule-associated protein-like 4 is a protein that in humans is encoded by the EML4 gene.[5]
This protein is involved in cancers when spliced with the anaplastic lymphoma kinase.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000143924 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000032624 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: EML4 echinoderm microtubule associated protein like 4".
^Choi YL, Takeuchi K, Soda M, Inamura K, Togashi Y, Hatano S, Enomoto M, Hamada T, Haruta H, Watanabe H, Kurashina K, Hatanaka H, Ueno T, Takada S, Yamashita Y, Sugiyama Y, Ishikawa Y, Mano H (July 2008). "Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer". Cancer Res. 68 (13): 4971–6. doi:10.1158/0008-5472.CAN-07-6158. PMID 18593892.
microtubule-associated protein-like 4 is a protein that in humans is encoded by the EML4 gene. This protein is involved in cancers when spliced with the anaplastic...
most frequently, the echinoderm microtubule-associated protein-like 4 (EML4) gene is fused to the anaplastic lymphoma kinase (ALK) gene. Less frequently...
on tumours with variations of anaplastic lymphoma kinase (ALK) such as an EML4-ALK translocation. They fall under the category of tyrosine kinase inhibitors...
carcinoma have a chromosomal rearrangement that generates a fusion gene between EML4 ('echinoderm microtubule-associated protein-like 4') and ALK ('anaplastic...
PMID 18768784. Li Y, Ye X, Liu J, Zha J, Pei L (January 2011). "Evaluation of EML4-ALK fusion proteins in non-small cell lung cancer using small molecule inhibitors"...
5' fusion partners, such as TFG, ATIC, CLTC1, TPM4, MSN, ALO17, MYH9. The EML4-ALK fusion gene is responsible for approximately 3-5% of non-small-cell lung...
adenocarcinomas of the lung. In ALK rearrangements, the most common partner gene is EML4. EML4-ALK fusions tend to occur in tumors that do not carry EGFR or KRAS mutations...
these proteins, Rikova performed RT-PCR and discovered ALK to be fused to EML4, a microtubule protein, triggering perpetual activation of the ALK tyrosine...
cell lung cancer that is characterized by the EML4-ALK fusion oncogene, and is approved by the FDA. EML4-ALK is found in some relatively young, never or...
source?] Inhibitor of EML4-ALK crizotinib shows benefit in a subset of non-small cell lung cancer that is characterized by the EML4-ALK fusion oncogene...
fusion of ALK tyrosine kinase domain with the promoter and 5’ region of EML4 in lung cancer. ALK-positive tumors are a clinically relevant subgroup as...
activity. Other genes that fuse with AKT found in IMT include: TFG, DCTN1, EML4, TPM3, TPM4, ATIC RANBP2 (most if not all RAMB2-ALK chimeric genes occur...
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