Dysbindin, short for dystrobrevin-binding protein 1, is a protein constituent of the dystrophin-associated protein complex (DPC) of skeletal muscle cells. It is also a part of BLOC-1, or biogenesis of lysosome-related organelles complex 1. Dysbindin was discovered by the research group of Derek Blake via yeast two-hybrid screening for binding partners of α-dystrobrevin.[5] In addition, dysbindin is found in neural tissue of the brain, particularly in axon bundles and especially in certain axon terminals, notably mossy fiber synaptic terminals in the cerebellum and hippocampus.[5] In humans, dysbindin is encoded by the DTNBP1 gene.[5]
^ abcGRCh38: Ensembl release 89: ENSG00000047579 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000057531 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abcBenson; Newey, SE; Martin-Rendon, E; Hawkes, R; Blake, DJ; et al. (2001). "Dysbindin, a novel coiled-coil-containing protein that interacts with the dystrobrevins in muscle and brain". J Biol Chem. 276 (26): 24232–41. doi:10.1074/jbc.M010418200. PMID 11316798.
Dysbindin, short for dystrobrevin-binding protein 1, is a protein constituent of the dystrophin-associated protein complex (DPC) of skeletal muscle cells...
reduced dysbindin expression. Increased NMDA receptors may point to the involvement of glutamate-dopamine interactions in schizophrenia. Dysbindin, which...
antipsychotic clozapine. Dysbindin is a protein coded for by the gene DTNBP1, which has been linked to schizophrenia. Dysbindin may be involved in the changes...
FOXP2 (which is linked to a familial language disorder and autism) and dysbindin 1 genes43,44. This distal explanation not only does not explain clanging...
Hohoff, Christa; Birosova, Eva; Arolt, Volker; Baune, Bernhard T. (2011). "Dysbindin (DTNBP1) – A role in psychotic depression?". Journal of Psychiatric Research...
Dysbindin domain-containing protein 2 is a protein that in humans is encoded by the DBNDD2 gene. GRCh38: Ensembl release 89: ENSG00000244274 – Ensembl...
reviews suggested that the evidence was strongest for two genes known as dysbindin (DTNBP1) and neuregulin (NRG1), and that a number of other genes (such...
indicated in children diagnosed with schizophrenia that include: neuregulin, dysbindin, D-amino acid oxidase, proline dehydrogenase, catechol-Omethyltransferase...
HIV-1 genes. TRIM32 has been shown to interact with: actin, ABI2 c-Myc, dysbindin, and piasy, Currently, TRIM32 is believed to employ two different mechanisms...
reading frame for this gene. MUTED has been shown to interact with BLOC1S2, Dysbindin and PLDN. GRCh38: Ensembl release 89: ENSG00000188428 – Ensembl, May 2017...
Starcevic M, Spencer MJ, Dell'Angelica EC (2006). "Reinvestigation of the dysbindin subunit of BLOC-1 (biogenesis of lysosome-related organelles complex-1)...
dock vesicles. SNAPAP has been shown to interact with: BLOC1S1, BLOC1S2, Dysbindin, PLDN, RGS7, SNAP-25, SNAP23, and TRPV1. GRCh38: Ensembl release 89: ENSG00000143553...
V. E. (2012). "Polymorphism of serotonin receptor genes (5-HTR2A) and dysbindin (DTNBP1) and individual components of short-term verbal memory processes...
Benson M.A., Newey S.E., Martin-Rendon E., Hawkes R. and Blake D.J. (2001) Dysbindin, a novel coiled-coil containing protein that interacts with the dystrobrevins...
magnitude. On the contrary, proteins being homologous to CK1BP (e.g. dysbindin or BLOC-1 [biogenesis of lysosome-related organelles complex-1]) are able...
(2003). "Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1)"...
additional to α-dystrobrevin-binding proteins: β-synemin, syncoilin, and dysbindin. Syncoilin and β-synemin are both intermediate filament proteins. The...
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