Recovery of biosynthetic products from natural sources
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Downstream processing refers to the recovery and the purification of biosynthetic products, particularly pharmaceuticals, from natural sources such as animal tissue, plant tissue or fermentation broth, including the recycling of salvageable components as well as the proper treatment and disposal of waste. It is an essential step in the manufacture of pharmaceuticals such as antibiotics, hormones (e.g. insulin and human growth hormone), antibodies (e.g. infliximab and abciximab) and vaccines; antibodies and enzymes used in diagnostics; industrial enzymes; and natural fragrance and flavor compounds. Downstream processing is usually considered a specialized field in biochemical engineering, which is itself a specialization within chemical engineering. Many of the key technologies were developed by chemists and biologists for laboratory-scale separation of biological and synthetic products, whilst the role of biochemical and chemical engineers is to develop the technologies towards larger production capacities.
Downstream processing and analytical bioseparation both refer to the separation or purification of biological products, but at different scales of operation and for different purposes. Downstream processing implies manufacture of a purified product fit for a specific use, generally in marketable quantities, while analytical bioseparation refers to purification for the sole purpose of measuring a component or components of a mixture, and may deal with sample sizes as small as a single cell.
and 22 Related for: Downstream processing information
Downstreamprocessing refers to the recovery and the purification of biosynthetic products, particularly pharmaceuticals, from natural sources such as...
upstream are processed to meet purity and quality requirements. Downstreamprocessing is usually divided into three main sections: cell disruption, a...
or Southern blotting for further characterization. Electrophoresis is a process that enables the sorting of molecules based on charge, size, or shape....
Protein precipitation is widely used in downstreamprocessing of biological products in order to concentrate proteins and purify them from various contaminants...
bioprocess is composed mainly of three stages—upstream processing, bioreaction, and downstreamprocessing—to convert raw material to finished product. The raw...
of the mold is designed to allow for ease of ingot handling and downstreamprocessing. Finally, the mold is designed to minimize melt wastage and aid...
but the water content leads to corrosion or is incompatible with downstreamprocessing. Removal of water is achieved by cryogenic condensation, absorption...
combines a number of methods to produce potable or drinking water. Downstreamprocessing refers to purification of chemicals, pharmaceuticals and food ingredients...
temperatures above 850 °C such that elemental sulfur precipitates in the downstreamprocess gas cooler. The H2S content and the concentration of other combustible...
triphosphate (GTP) as phosphate source. Glucose is obtained after further downstreamprocessing. The urea cycle is a metabolic pathway that results in the formation...
exclusively, albeit at a lower concentration, and thus require more downstreamprocessing for cobalt extraction. Several methods exist to separate cobalt...
medium-term priorities are: emerging industrial technology for downstreamprocessing; infrastructure technology for the economic corridors; knowledge-based...
uniquely dedicated to face processing, as proposed by Nancy Kanwisher and others, or whether it participates in the processing of other objects. The expertise...
of the different protein purification methods and optimizing the downstreamprocessing are critical to minimize production costs while maintaining the...
Hinrichs, Jörg; Weiss, Jochen (24 September 2020). "Cultivation and downstreamprocessing of microalgae and cyanobacteria to generate protein-based technofunctional...
processing, the mathematical manipulation of an information signal Digital signal processor, a microprocessor designed for digital signal processing Dynamic...
some elements of the upstream and downstream sectors. For example, the midstream sector may include natural gas processing plants that purify the raw natural...
Hinrichs, Jörg; Weiss, Jochen (24 September 2020). "Cultivation and downstreamprocessing of microalgae and cyanobacteria to generate protein-based technofunctional...
2009. Retrieved 12 July 2009. del Rosario Alemán, María (2007). "DownstreamProcessing: A Revalidation Study of Viral Clearance in the Purification of...
absorption or retention. Diseases related to lysine are a result of the downstreamprocessing of lysine, i.e. the incorporation into proteins or modification...
Nikolaos E. (ed.), "Protein Purification: An Overview", Protein DownstreamProcessing: Design, Development and Application of High and Low-Resolution...
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