Dextran drug delivery systems involve the use of the natural glucose polymer dextran in applications as a prodrug, nanoparticle, microsphere, micelle, and hydrogel drug carrier in the field of targeted and controlled drug delivery. According to several in vitro and animal research studies, dextran carriers reduce off-site toxicity and improve local drug concentration at the target tissue site.[1] This technology has significant implications as a potential strategy for delivering therapeutics to treat cancer, cardiovascular diseases, pulmonary diseases, bone diseases, liver diseases, colonic diseases, infections, and HIV.[1][2][3]
Although there are many FDA approved natural polymeric-based drug carriers available for clinical use, dextran has failed to obtain any clinical applications. Research must address several challenges and obstacles associated with dextran before it can become a viable, clinically approved drug delivery strategy.[4]
^ abChen, Fang; Huang, Gangliang; Huang, Hualiang (2020-02-15). "Preparation and application of dextran and its derivatives as carriers". International Journal of Biological Macromolecules. 145: 827–834. doi:10.1016/j.ijbiomac.2019.11.151. ISSN 0141-8130. PMID 31756474. S2CID 208234260.
^Basan, Hasan; Gümüşderelioğlu, Menemşe; Tevfik Orbey, M. (2007-01-01). "Release characteristics of salmon calcitonin from dextran hydrogels for colon-specific delivery". European Journal of Pharmaceutics and Biopharmaceutics. 65 (1): 39–46. doi:10.1016/j.ejpb.2006.07.008. ISSN 0939-6411. PMID 16950607.
^Simonsen, Lene; Hovgaard, Lars; Mortensen, Per Brøbech; Brøndsted, Helle (1995-12-01). "Dextran hydrogels for colon-specific drug delivery. V. Degradation in human intestinal incubation models". European Journal of Pharmaceutical Sciences. 3 (6): 329–337. doi:10.1016/0928-0987(95)00023-6. ISSN 0928-0987.
^Huang, Shiyu; Huang, Gangliang (2019-07-01). "The dextrans as vehicles for gene and drug delivery". Future Medicinal Chemistry. 11 (13): 1659–1667. doi:10.4155/fmc-2018-0586. ISSN 1756-8919. PMID 31469330. S2CID 201673842.
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