A nanogel is a polymer-based, crosslinked hydrogel particle on the sub-micron scale.[1][2][3] These complex networks of polymers present a unique opportunity in the field of drug delivery at the intersection of nanoparticles and hydrogel synthesis.[1][2][3] Nanogels can be natural, synthetic, or a combination of the two and have a high degree of tunability in terms of their size, shape, surface functionalization, and degradation mechanisms.[1][2][3] Given these inherent characteristics in addition to their biocompatibility and capacity to encapsulate small drugs and molecules, nanogels are a promising strategy to treat disease and dysfunction by serving as delivery vehicles capable of navigating across challenging physiological barriers within the body.[1][2][3]
Nanogels are not to be confused with Nanogel aerogel, a lightweight thermal insulator, or with nanocomposite hydrogels (NC gels), which are nanomaterial-filled, hydrated, polymeric networks that exhibit higher elasticity and strength relative to traditionally made hydrogels.
^ abcdCuggino, Julio César; Blanco, Ernesto Rafael Osorio; Gugliotta, Luis Marcelino; Alvarez Igarzabal, Cecilia Inés; Calderón, Marcelo (August 2019). "Crossing biological barriers with nanogels to improve drug delivery performance". Journal of Controlled Release. 307: 221–246. doi:10.1016/j.jconrel.2019.06.005. PMID 31175895. S2CID 182947913.
^ abcdSuhail, Muhammad; Rosenholm, Jessica M; Minhas, Muhammad Usman; Badshah, Syed Faisal; Naeem, Abid; Khan, Kifayat Ullah; Fahad, Muhammad (2019-11-01). "Nanogels as drug-delivery systems: a comprehensive overview". Therapeutic Delivery. 10 (11): 697–717. doi:10.4155/tde-2019-0010. ISSN 2041-5990. PMID 31789106. S2CID 208536874.
A nanogel is a polymer-based, crosslinked hydrogel particle on the sub-micron scale. These complex networks of polymers present a unique opportunity in...
particularly when a dust or fine fragments may occur. Carbon nanofoam Fogbank Nanogel This article incorporates text by Elizabeth Barrios, David Fox, Yuen Yee...
and carbohydrates) and large non-polymeric molecules such as lipids, nanogels and macrocycles. Synthetic fibers and experimental materials such as carbon...
Corey-Chaykovsky reagent and adrenochrome. In biomedical engineering, protein nanogels made by the in situ polymerization method provide a versatile platform...
used to prepare protein nanogels that help facilitate the storage and delivery of protein. The preparation of such nanogels via the in situ polymerization...
Ye C, Cheng M, Ma L, Zhang T, Sun Z, Yu C, et al. (May 2022). "Oxytocin Nanogels Inhibit Innate Inflammatory Response for Early Intervention in Alzheimer's...
mechanical fields. Nanocomposite hydrogels are not to be confused with nanogel, a nanoparticle composed of a hydrogel. The synthesis of nanocomposite...
been studied to effectively target specific tissues, including liposomes, nanogels, and other nanotechnologies. Controlled or modified-release formulations...
RP, Opanasopit P, Khutoryanskiy VV (October 2016). "Maleimide-bearing nanogels as novel mucoadhesive materials for drug delivery". Journal of Materials...
Immunity Against Nontypeable Haemophilus influenzae Infection by a Cationic Nanogel–Based P6 Nasal Vaccine". Frontiers in Immunology. 13: 819859. doi:10.3389/fimmu...
Nidhi; Kikon, NY; Ali, Ashif; Jakhmola, Vikas. "Hopes and hurdles of nanogels in the treatment of ocular diseases". Journal of Applied Pharmaceutical...
an Apoptosis-Independent Role for p53 in Self-Renewal June 2010 Hybrid nanogels by encapsulation of lanthanide-doped LaF3 nanoparticles as elemental tags...
polymeric materials with biologically derived molecules. She has designed nanogels and polymers to stabilise biomolecules to temperature variations and agitation...
Yan; Liu, Hongzhuo (2018-01-01). "Research progress of self-assembled nanogel and hybrid hydrogel systems based on pullulan derivatives". Drug Delivery...
are enclosed in a semi-translucent polycarbonate cladding injected with nanogel, creating a diaphanous skin and keeping the structure as light as possible...
T.; Ventura, Judy; Zhuang, Jiaming; Thayumanavan, S. (2012). "Polymer nanogels: A versatile nanoscopic drug delivery platform". Advanced Drug Delivery...
Fahmy, Tarek M.; Tsokos, George C. (15 December 2015). "Cutting Edge: Nanogel-Based Delivery of an Inhibitor of CaMK4 to CD4 + T Cells Suppresses Experimental...
F (2015). "Efficient reduction and pH co-triggered DOX-loaded magnetic nanogel carrier using disulfide crosslinking". Mater. Sci. Eng. C. 46: 41–51. doi:10...
Opanasopit, Praneet; Khutoryanskiy, Vitaliy V. (2016-10-12). "Maleimide-bearing nanogels as novel mucoadhesive materials for drug delivery". Journal of Materials...
Global Information