Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Chemical compound
A deoxyadenosyl radical is a free radical that is structurally related to adenosine by removal of a 5′-hydroxy group from adenosine. This radical occurs in nature as a reactive intermediate. It is generated by radical SAM enzymes and by some varieties of vitamin B12.[1] The deoxyadenosyl radical abstracts hydrogen atoms from substrates, causing rearrangements and other post transcriptional modifications required for biosynthesis.[2]
^Jennifer Bridwell-Rabb; Tsehai A. J. Grell; Catherine L. Drennan (2018). "A Rich Man, Poor Man Story of S-Adenosylmethionine and Cobalamin Revisited". Annual Review of Biochemistry. 87: 555–84. doi:10.1146/annurev-biochem-062917-012500. PMID 29925255. S2CID 49354135.
^Broderick, J. B.; Duffus, B. R.; Duschene, K. S.; Shepard, E. M. (2014). "Radical S-Adenosylmethionine Enzymes". Chemical Reviews. 114 (8): 4229–4317. doi:10.1021/cr4004709. PMC 4002137. PMID 24476342.
and 9 Related for: Deoxyadenosyl radical information
A deoxyadenosylradical is a free radical that is structurally related to adenosine by removal of a 5′-hydroxy group from adenosine. This radical occurs...
(SAM) to generate a radical, usually a 5′-deoxyadenosylradical (5'-dAdo), as a critical intermediate. These enzymes utilize this radical intermediate to...
a cofactor in radical-mediated 1,2-carbon skeleton rearrangements. These processes require the formation of the deoxyadenosylradical through homolytic...
a radical generated with the stabilization of a binuclear manganese center. Class II reductases generate the free radical 5’-deoxyadenosylradical from...
chemistry of vitamin B12, allowing it to serve as a donor of deoxyadenosylradical (radical alkyl source) and as a methyl cation equivalent (electrophilic...
generating a 5’-deoxyadenosylradical (5’-dA). This carbon radical abstracts a hydrogen from dethiobiotin, forming a dethiobiotinyl C9 carbon radical, which is...
which cleaves a part of the structure and forms a 5'-deoxyadenosylradical. This 5'-deoxyadenosylradical will then remove a hydrogen atom from the substrate...
is used by this enzyme to produce 5'-deoxyadenosyl 5'-radical (5'-dA). Lipoyl synthase itself uses this radical to abstract hydrogens from the 6th and...
otherwise known as radical SAM enzymes, are metalloproteins that cleave S-adenosyl-L-methionine into L-methionine and a 5'-deoxyadenosyl 5'-radical (5'-dA). 5'-dA...
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