Methylthiotransferases are enzymes of the radical S-adenosyl methionine (radical SAM) superfamily. These enzymes catalyze the addition of a methylthio group to various biochemical compounds including tRNA and proteins.[1] Methylthiotransferases are classified into one of four classes based on their substrates and mechanisms.[2] All methylthiotransferases have been shown to contain two Fe-S clusters, one canonical cluster and one auxiliary cluster, that both function in the addition of the methylthio group to the substrate.[3]
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Methylthiotransferases are enzymes of the radical S-adenosyl methionine (radical SAM) superfamily. These enzymes catalyze the addition of a methylthio...
(Cdk5 regulatory associated protein 1-like 1) is a gene in the methylthiotransferase family. The complete physiological function and implications of...
that contain two [4Fe-4S]+ clusters and one radical SAM domain. Methylthiotransferases play a major role in catalyzing methylthiolation on tRNA nucleotides...
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