Demecarium bromide, trade name Humorsol, is a carbamate parasympathomimetic drug that acts as an acetylcholinesterase inhibitor, and is used as a glaucoma medication. It is applied directly to the eye in order to reduce elevated intraocular pressure associated with glaucoma.[1]
Demecarium causes constriction of the pupil (miosis), which improves the drainage of the fluid in the eye (aqueous humour).[2] As demecarium reversibly inhibits cholinesterase, it can be administered less frequently than other parasympathomimetic drugs, such as carbachol.[3]
Commercially produced demecarium bromide solution, previously sold under the trade name Humorsol,[4] is no longer available,[3] although solutions of demecarium can be compounded.[5]
^Jeske AH, ed. (2014). "Demecarium bromide". Mosby's dental drug reference (11th ed.). St. Louis, Missouri: Elsevier Mosby. p. 374. ISBN 978-0-323-16916-5.
^Stein HA, Stein RM, Freeman M (2012). "Demecarium bromide (Humorsol)". Ophthalmic dictionary and vocabulary builder for eye care professionals (4th ed.). New Delhi: Jaypee Brothers Medical. p. 103. ISBN 9789350253656.
^ abMaggs DJ, Miller PE, Ofri R (2013). "Indirect-acting parasympathomimetic agents". Slatter's Fundamentals of Veterinary Ophthalmology (5th ed.). St. Louis, Missouri: Elsevier. p. 51. ISBN 978-1-4377-2367-0.
^Edmunds MW, Mayhew MS (2013). Pharmacology for the primary care provider (4th ed.). Elsevier Health Sciences. p. 174. ISBN 978-0-323-08790-2.
^Alario AF, Strong TD, Pizzirani S (November 2015). "Medical Treatment of Primary Canine Glaucoma". The Veterinary Clinics of North America. Small Animal Practice. 45 (6): 1235–59, vi. doi:10.1016/j.cvsm.2015.06.004. PMID 26319445.
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