regulation of transcription regulatory region DNA binding
regulation of receptor signaling pathway via JAK-STAT
positive regulation of transcription by RNA polymerase II
positive regulation of cell population proliferation
histone H3-K79 methylation
DNA damage checkpoint signaling
DNA repair
chromatin organization
regulation of cell cycle
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
84444
208266
Ensembl
ENSG00000104885
ENSMUSG00000061589
UniProt
Q8TEK3
n/a
RefSeq (mRNA)
NM_032482
NM_199322
RefSeq (protein)
NP_115871
n/a
Location (UCSC)
Chr 19: 2.16 – 2.23 Mb
Chr 10: 80.59 – 80.63 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
DOT1-like (Disruptor of telomeric silencing 1-like), histone H3K79 methyltransferase (S. cerevisiae), also known as DOT1L, is a protein found in humans, as well as other eukaryotes.[5]
DOT1L has been reported to play an important role in the processes of mixed-lineage leukemia (MLL)-rearranged leukemias[6]
Small molecule inhibitors of Dot1L catalytic activity have been developed.[7][8]
All three forms of H3K79 methylation (H3K79me1; H3K79me2; H3K79me3) are catalyzed by DOT1 in yeast or DOT1L in mammals. H3K79 methylation participates in the DNA damage response and has multiple roles in nucleotide excision repair and sister chromatid recombinational repair.[9]
^ abcGRCh38: Ensembl release 89: ENSG00000104885 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000061589 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: DOT1L DOT1-like, histone H3 methyltransferase (S. cerevisiae)".
^Slany RK (2016). "The molecular mechanics of mixed lineage leukemia". Oncogene. 35 (40): 5215–5223. doi:10.1038/onc.2016.30. PMID 26923329. S2CID 34116587.
^Yao Y, Chen P, Diao J, Cheng G, Deng L, Anglin JL, Prasad BV, Song Y (2011). "Selective inhibitors of histone methyltransferase DOT1L: design, synthesis, and crystallographic studies". Journal of the American Chemical Society. 133 (42): 16746–9. doi:10.1021/ja206312b. PMC 3492951. PMID 21936531.
^Chen S, Li L, Chen Y, Hu J, Liu J, Liu YC, Liu R, Zhang Y, Meng F, Zhu K, Lu J, Zheng M, Chen K, Zhang J, Jiang H, Yao Z, Luo C (2016). "Identification of Novel Disruptor of Telomeric Silencing 1-like (DOT1L) Inhibitors through Structure-Based Virtual Screening and Biological Assays". Journal of Chemical Information and Modeling. 56 (3): 527–34. doi:10.1021/acs.jcim.5b00738. PMID 26914852.
^Chen Y, Zhu WG (July 2016). "Biological function and regulation of histone and non-histone lysine methylation in response to DNA damage". Acta Biochim. Biophys. Sin. (Shanghai). 48 (7): 603–16. doi:10.1093/abbs/gmw050. PMID 27217472.
methyltransferase (S. cerevisiae), also known as DOT1L, is a protein found in humans, as well as other eukaryotes. DOT1L has been reported to play an important...
specific TF according to literature or domain structure – No motif [158] DOT1L ENSG00000104885 AT hook Likely sequence specific TF according to literature...
Lefterova MI, Ying L, Stonestrom AJ, Schupp M, Zhuo D, et al. (April 2008). "DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene...
Vakoc AL, Kim JE, Chen J, Lazar MA, Blobel GA, Vakoc CR (April 2008). "DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene...
Vakoc AL, Kim JE, Chen J, Lazar MA, Blobel GA, Vakoc CR (April 2008). "DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene...
Li W, Li H, Shi X (2014). "AF9 YEATS domain links histone acetylation to DOT1L-mediated H3K79 methylation". Cell. 159 (3): 558–71. doi:10.1016/j.cell.2014...
methylation (H3K79me1; H3K79me2; H3K79me3) are catalyzed by DOT1 in yeast or DOT1L in mammals. H3K79 methylation participates in the DNA damage response and...
Feng Q, Lin Y, Jiang Q, Li Y, Coffield VM, Su L, Xu G, Zhang Y (2005). "hDOT1L links histone methylation to leukemogenesis". Cell. 121 (2): 167–78. doi:10...
of Af9 with the methyltransferase DOT1L, which methylates histone H3 lysine 79 (H3K79). Af9 association with DOT1L enhances methylation of H3K79 at the...