MLLT10 information

MLLT10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5DAG, 5DAH
Identifiers
Aliases	MLLT10, AF10, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10, histone lysine methyltransferase DOT1L cofactor, MLLT10 histone lysine methyltransferase DOT1L cofactor
External IDs	OMIM: 602409; MGI: 1329038; HomoloGene: 20973; GeneCards: MLLT10; OMA:MLLT10 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	21,743,630 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	18,212,388 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; epithelium of colon; ; Achilles tendon; ; right testis; ; left testis; ; secondary oocyte; ; sperm; ; tibia; ; testicle; ; skin of thigh;
	Top expressed in
	spermatocyte; ; genital tubercle; ; tail of embryo; ; secondary oocyte; ; primary oocyte; ; seminiferous tubule; ; zygote; ; neural layer of retina; ; spermatid; ; granulocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; protein binding; metal ion binding; chromatin binding; nucleosome binding; histone binding;
Cellular component	nucleoplasm; nucleus; cytosol; protein-containing complex;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	8028
	17354
	ENSG00000078403
	ENSMUSG00000026743
	P55197
	O54826
NM_001009569; NM_001195626; NM_001195627; NM_001195628; NM_001195630;
	NM_004641; NM_001324296; NM_001324297
	NM_001252560; NM_001252561; NM_010804
NP_001182555; NP_001182556; NP_001182557; NP_001182559; NP_001311225;
	NP_001311226; NP_004632
	NP_001239489; NP_001239490; NP_034934
	Wikidata
View/Edit Human	View/Edit Mouse

Protein AF-10 is a protein that in humans is encoded by the MLLT10 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000078403 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026743 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chaplin T, Ayton P, Bernard OA, Saha V, Della Valle V, Hillion J, Gregorini A, Lillington D, Berger R, Young BD (Apr 1995). "A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia". Blood. 85 (6): 1435–41. doi:10.1182/blood.V85.6.1435.bloodjournal8561435. PMID 7888665.
^ "Entrez Gene: MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000078403 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026743 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7888665-5] Chaplin T, Ayton P, Bernard OA, Saha V, Della Valle V, Hillion J, Gregorini A, Lillington D, Berger R, Young BD (Apr 1995). "A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia". Blood. 85 (6): 1435–41. doi:10.1182/blood.V85.6.1435.bloodjournal8561435. PMID 7888665.

[entrez-6] "Entrez Gene: MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10".

MLLT10 information

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MLLT10

SS18