DNA polymerase eta information

POLH
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2I5O, 4RNM, 4J9O, 4YQW, 4YR0, 4ECX, 4ECS, 4ECT, 2LSK, 4DL5, 4ECR, 4DL3, 4J9K, 3MR5, 4J9N, 3SI8, 4YP3, 4O3N, 5EWE, 4ECU, 4DL6, 3MR6, 4RNN, 3MR3, 4ECY, 4O3P, 4RNO, 4ECQ, 4O3O, 4O3S, 4ECV, 4J9P, 4Q8F, 4ED3, 4ECZ, 4DL2, 4ECW, 3WUP, 5EWF, 4ED7, 4YR2, 4EEY, 4ED8, 4J9S, 3JAA, 4J9M, 4J9Q, 3MR2, 3TQ1, 4ED6, 4DL7, 4J9R, 4ED0, 4YR3, 4O3Q, 4ED1, 4J9L, 4DL4, 4O3R, 4RU9, 5EWG, 4ED2, 4Q8E, 5KG6, 5DGB, 5KFT, 5DG8, 5KFV, 5KFH, 5KG7, 5KG0, 5KFN, 5KFZ, 5KG1, 5KFX, 5KFC, 5KFU, 5KFA, 5KFK, 5KFI, 5KG4, 5KFQ, 5KFO, 5KFE, 5KFD, 5KFG, 5KG2, 5KFR, 5KFP, 5KG3, 5KFM, 5KFW, 5DGA, 5KFB, 5DG7, 5KFF, 5KFJ, 5DG9, 5L9X, 5KG5, 5KFS, 5KFL, 5KFY
Identifiers
Aliases	POLH, RAD30, RAD30A, XP-V, XPV, DNA polymerase eta, polymerase (DNA) eta
External IDs	OMIM: 603968 MGI: 1891457 HomoloGene: 38189 GeneCards: POLH
Gene location (Human)
Chr.	Chromosome 6 (human)
End	43,620,523 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	46,513,571 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; trabecular bone; ; lower lobe of lung; ; nipple; ; thymus; ; oral cavity; ; vena cava; ; caput epididymis; ; corpus epididymis; ; gums;
	Top expressed in
	spermatocyte; ; Paneth cell; ; cumulus cell; ; body of femur; ; fossa; ; seminal vesicula; ; thymus; ; condyle; ; hair follicle; ; endocardial cushion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; DNA binding; nucleotidyltransferase activity; metal ion binding; damaged DNA binding; protein binding; DNA-directed DNA polymerase activity;
Cellular component	nucleoplasm; nucleus; cytosol; replication fork; site of double-strand break;
Biological process	DNA synthesis involved in DNA repair; pyrimidine dimer repair; DNA biosynthetic process; postreplication repair; error-free translesion synthesis; regulation of DNA repair; cellular response to DNA damage stimulus; DNA replication; cellular response to UV-C; translesion synthesis; response to UV-C; DNA repair; response to radiation; error-prone translesion synthesis;
	Sources:Amigo / QuickGO
Orthologs
	5429
	80905
	ENSG00000170734
	ENSMUSG00000023953
	Q9Y253
	Q9JJN0
	NM_001291969; NM_001291970; NM_006502
	NM_030715; NM_001364947
	NP_001278898; NP_001278899; NP_006493
	NP_109640; NP_001351876
	Wikidata
View/Edit Human	View/Edit Mouse

DNA polymerase eta (Pol η), is a protein that in humans is encoded by the POLH gene.^[5]^[6]^[7]

DNA polymerase eta is a eukaryotic DNA polymerase involved in the DNA repair by translesion synthesis. The gene encoding DNA polymerase eta is POLH, also known as XPV, because loss of this gene results in the disease xeroderma pigmentosum. Polymerase eta is particularly important for allowing accurate translesion synthesis of DNA damage resulting from ultraviolet radiation or UV.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170734 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023953 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: POLH polymerase (DNA directed), eta".
^ Masutani C, Kusumoto R, Yamada A, Dohmae N, Yokoi M, Yuasa M, Araki M, Iwai S, Takio K, Hanaoka F (June 1999). "The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta". Nature. 399 (6737): 700–4. Bibcode:1999Natur.399..700M. doi:10.1038/21447. PMID 10385124. S2CID 4429698.
^ Johnson RE, Kondratick CM, Prakash S, Prakash L (July 1999). "hRAD30 mutations in the variant form of xeroderma pigmentosum". Science. 285 (5425): 263–5. doi:10.1126/science.285.5425.263. PMID 10398605.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170734 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023953 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: POLH polymerase (DNA directed), eta".

[pmid10385124-6] Masutani C, Kusumoto R, Yamada A, Dohmae N, Yokoi M, Yuasa M, Araki M, Iwai S, Takio K, Hanaoka F (June 1999). "The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta". Nature. 399 (6737): 700–4. Bibcode:1999Natur.399..700M. doi:10.1038/21447. PMID 10385124. S2CID 4429698.

[pmid10398605-7] Johnson RE, Kondratick CM, Prakash S, Prakash L (July 1999). "hRAD30 mutations in the variant form of xeroderma pigmentosum". Science. 285 (5425): 263–5. doi:10.1126/science.285.5425.263. PMID 10398605.

DNA polymerase eta information

and 26 Related for: DNA polymerase eta information

DNA polymerase eta

POLQ

DNA polymerase

DNA repair

POLI

DNA mismatch repair

Crosslinking of DNA

POLK

Eta

Alkylating antineoplastic agent

Oxidative stress

Proliferating cell nuclear antigen

Hereditary cancer syndrome

REV1

REV3L

Copy number variation

Oncogenomics

Postreplication repair

CHTF18

RAD18

Xeroderma pigmentosum

Centenarian

Capillary electrophoresis

Polymer

Glucocorticoid receptor

Microbial toxin