Thus, the two substrates of this enzyme are O3-acetyl-L-serine and hydrogen sulfide, whereas its two products are L-cysteine and acetate.
This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is O3-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase. Other names in common use include O-acetyl-L-serine sulfhydrylase, O-acetyl-L-serine sulfohydrolase, O-acetylserine (thiol)-lyase, O-acetylserine (thiol)-lyase A, O-acetylserine sulfhydrylase, O3-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide), acetylserine sulfhydrylase, cysteine synthetase, S-sulfocysteine synthase, 3-O-acetyl-L-serine:hydrogen-sulfide, and 2-amino-2-carboxyethyltransferase. This enzyme participates in 3 metabolic pathways: cysteine metabolism, selenoamino acid metabolism, and sulfur metabolism. It employs one cofactor, pyridoxal phosphate.
In enzymology, a cysteinesynthase (EC 2.5.1.47) is an enzyme that catalyzes the chemical reaction O3-acetyl-L-serine + hydrogen sulfide ⇌ {\displaystyle...
transacetylase. The enzyme cysteinesynthase, using sulfide sources, converts this ester into cysteine, releasing acetate. The cysteine sulfhydryl group is nucleophilic...
common use include: β-thionase, cysteinesynthase, L-serine hydro-lyase (adding homocysteine), methylcysteine synthase, serine sulfhydrase, and serine...
from L-glutamate and L-cysteine. This conversion requires the enzyme glutamate–cysteine ligase (GCL, glutamate cysteinesynthase). This reaction is the...
succinyl group of a homoserine with cysteine via its thiol group to form cystathionine (catalysed by cystathionine γ-synthase, which is encoded by metB in E...
sulfurylase) is an enzyme with systematic name persulfurated L-cysteine desulfurase:(molybdopterin-synthase sulfur-carrier protein)-Gly-Gly sulfurtransferase. This...
characteristic reaction of β-ketoacyl-ACP synthase III is malonyl-ACP + acetyl-CoA => acetoacyl-ACP + CO2 + CoA. Cysteine, histidine, and asparagine form the...
(Pi). ATP synthase is a molecular machine. The overall reaction catalyzed by ATP synthase is: ADP + Pi + 2H+out ⇌ ATP + H2O + 2H+in ATP synthase lies across...
acid methionine due to a deficiency of cystathionine beta synthase or methionine synthase. It is an inherited autosomal recessive trait, which means...
Cysteine metabolism refers to the biological pathways that consume or create cysteine. The pathways of different amino acids and other metabolites interweave...
homocysteine homeostasis than methionine synthase. Homocysteine can be converted to cysteine. (5) Cystathionine-β-synthase (an enzyme which requires pyridoxal...
Thymidylate synthase (TS) (EC 2.1.1.45) is an enzyme that catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate...
cofactor, a serine-attached 4'-phosphopantetheine KS: Keto-synthase with an SH group on a cysteine side-chain KR: Ketoreductase DH: Dehydratase ER: Enoylreductase...
YH, Murakoshi I (1987). "Difference between uracilylalanine synthases and cysteinesynthases in Pisum sativum". Phytochemistry. 26 (10): 2699–2704. doi:10...
where C and R denote cysteine and arginine residues respectively. Pyridoxal phosphate (PLP) utilizing enzymes such as cysteinesynthase have also been said...
S-alkyl-L-cysteine S-oxide ⇌ {\displaystyle \rightleftharpoons } an alkyl sulfenate + 2-aminoacrylate Hence, this enzyme has one substrate, S-alkyl-L-cysteine S-oxide...
1M0T, 1M0W, 2GLT, and 2HGS. Glutathione synthase catalyzes the chemical reaction ATP + gamma-L-glutamyl-L-cysteine + glycine ⇌ {\displaystyle \rightleftharpoons...
L-methionine or conversion to L-cysteine. Mammals biosynthesize the amino acid cysteine via homocysteine. Cystathionine β-synthase catalyses the condensation...
enzymology, a homoglutathione synthase (EC 6.3.2.23) is an enzyme that catalyzes the chemical reaction ATP + γ-L-glutamyl-L-cysteine + β-alanine ⇌ {\displaystyle...
cell along with the regulation of enzymatic activity. In E. coli citrate synthase, the enzyme involved in the condensation reaction initiating the Citric...
homocysteine and serine by cystathionine beta synthase (upper reaction in the diagram below). It is then cleaved into cysteine and α-ketobutyrate by cystathionine...
sub-class: Alkyl and aryl transferases. Cysteinesynthase, for example, catalyzes the formation of acetic acids and cysteine from O3-acetyl-L-serine and hydrogen...
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