Ketoacyl synthases (KSs) catalyze the condensation reaction of acyl-CoA or acyl-acyl ACP with malonyl-CoA to form 3-ketoacyl-CoA or with malonyl-ACP to form 3-ketoacyl-ACP. This reaction is a key step in the fatty acid synthesis cycle, as the resulting acyl chain is two carbon atoms longer than before. KSs exist as individual enzymes, as they do in type II fatty acid synthesis and type II polyketide synthesis, or as domains in large multidomain enzymes, such as type I fatty acid synthases (FASs) and polyketide synthases (PKSs). KSs are divided into five families: KS1, KS2, KS3, KS4, and KS5.[1]
The general mechanism for Ketoacyl synthases
^Chen, Yingfei; Kelly, Erin E.; Masluk, Ryan P.; Nelson, Charles L.; Cantu, David C.; Reilly, Peter J. (2011-10-01). "Structural classification and properties of ketoacyl synthases". Protein Science. 20 (10): 1659–1667. doi:10.1002/pro.712. ISSN 1469-896X. PMC 3218358. PMID 21830247.
Ketoacylsynthases (KSs) catalyze the condensation reaction of acyl-CoA or acyl-acyl ACP with malonyl-CoA to form 3-ketoacyl-CoA or with malonyl-ACP to...
subunits, in which three catalytic domains in the N-terminal section (-ketoacylsynthase (KS), malonyl/acetyltransferase (MAT), and dehydrase (DH)), are separated...
anerobic polyketide synthase (PKS) pathway to synthesize DHA. The PKS pathway includes six enzymes namely, 3-ketoacylsynthase (KS), 2 ketoacyl-ACP-reductase...
the decarboxylative condensation with malonyl-CoA catalyzed by a ketoacylsynthase (KS) protein. The resulting acetoacetyl ACP is the simplest polyketide...
streaming, a method of processing streamed data Ketoacylsynthase, a domain of polyketide synthases with a thiol group on a cysteine side-chain kilosample...
The biosynthesis of lovastatin occurs via an iterative type I polyketide synthase (PKS) pathway. The six genes that encode enzymes that are essential for...
function from ketoacylsynthase (KAS) III, an early stage enzyme of type II fatty acid biosynthesis. Although higher plant chalcone synthases have been extensively...
Z, White SW, Rock CO (March 2001). "Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism"...
isomerization into the cis-3-decenoyl intermediate. FabB is a β-ketoacyl-ACP synthase that elongates and channels intermediates into the mainstream fatty...
Mripig A gene. PKS uses the domains acyl transferase, acetyl-CoA, ketoacylsynthase, acyl transferase, acyl carrier protein and the base units of acetyl-CoA...
and NRPS, EPOS P(epoP) module. The EPOS A contains a modified β-ketoacyl-synthase (malonyl-ACP decarboxylase, KSQ), an acyltransferase (AT), an enoyl...
"Mechanistic analysis of a type II polyketide synthase. Role of conserved residues in the beta-ketoacylsynthase-chain length factor heterodimer". Biochemistry...
Society Kas (drink), a brand of soft drink produced by PepsiCo Beta-ketoacyl-ACP synthase, a group of enzymes Kas is a Dutch style of closet for storing clothes...
is coupled to rhamnose at the OH-C(4’) position by the TiaF, a ketoacyl ACP synthase. This is followed by chlorination of the aryl moiety by the halogenase...
Kristin K; Parrish, Cynthia A (2014). "A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site". Nature Chemical Biology...
carrier protein biosynthesis locus and the nearby gene with the β-ketoacylsynthase domain are involved in the biosynthesis of galbonolides in Streptomyces...
by malonyl coenzyme A (after decarboxylation). This process produces 3-ketoacyl-CoA's as intermediates. The C=O (keto) group is replaced with CH2 via a...
from two distinct types of biochemical subunits or "building-blocks": ketoacyl and isoprene groups. Using this approach, lipids may be divided into eight...
(2011-07-20). "Nongenetic Reprogramming of a Fungal Highly Reducing Polyketide Synthase". Journal of the American Chemical Society. 133 (28): 10990–10998. doi:10...
dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit HADHB: hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme...
anthracimycin production. Anthracimycin is the product of a type I polyketide synthase (PKS). This modular synthetic pathway uses a trans-acyltransferase (AT)...
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