Cysteamine is an organosulfur compound with the formula HSCH2CH2NH2. A white, water-soluble solid, it contains both an amine and a thiol functional groups. It is often used as salts of the ammonium derivative [HSCH2CH2NH3]+[12] including the hydrochloride, phosphocysteamine, and the bitartrate.[13]The intermediate pantetheine is broken down into cysteamine and pantothenic acid.[13]
It is biosynthesized in mammals, including humans, by the degradation of coenzyme A. It is the biosynthetic precursor to the neurotransmitter hypotaurine.[14][13]
^"CYSTADROPS : Cysteamine Ophthalmic Solution" (PDF). Pdf.hres.ca. Archived (PDF) from the original on 10 June 2022. Retrieved 8 June 2022.
^"Genetic disorders". Health Canada. 9 May 2018. Retrieved 13 April 2024.
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^"Cystadrops 3.8 mg/mL eye drops solution - Summary of Product Characteristics (SmPC)". (emc). 19 June 2019. Archived from the original on 9 June 2020. Retrieved 9 June 2020.
^"Procysbi 25 mg gastro-resistant hard capsules - Summary of Product Characteristics (SmPC)". Medicines.org.uk. 17 September 2019. Archived from the original on 22 January 2021. Retrieved 9 June 2020.
^Cite error: The named reference USlabelCapsules was invoked but never defined (see the help page).
^Cite error: The named reference USlabelEye was invoked but never defined (see the help page).
^Cite error: The named reference USlabelExtcapsules was invoked but never defined (see the help page).
^Cite error: The named reference =Procysbi EPAR was invoked but never defined (see the help page).
^Cite error: The named reference Cystagon EPAR was invoked but never defined (see the help page).
^Cite error: The named reference Cystadrops EPAR was invoked but never defined (see the help page).
^Reid EE (1958). Organic Chemistry of Bivalent Sulfur. Vol. 1. New York: Chemical Publishing Company, Inc. pp. 398–399.
^ abcBesouw M, Masereeuw R, van den Heuvel L, Levtchenko E (August 2013). "Cysteamine: an old drug with new potential". Drug Discovery Today. 18 (15–16): 785–792. doi:10.1016/j.drudis.2013.02.003. PMID 23416144.
^Singer TP (1975). "Oxidative Metabolism of Cysteine and Cystine". In Greenberg DM (ed.). Metabolic pathways: Metabolism of sulfur compounds. Vol. 7 (3rd ed.). New York: Academic Press. p. 545. ISBN 9780323162081. Archived from the original on 7 June 2021. Retrieved 11 January 2017.
Cysteamine is an organosulfur compound with the formula HSCH2CH2NH2. A white, water-soluble solid, it contains both an amine and a thiol functional groups...
nonnephropathic Cystinosis is normally treated with cysteamine, which is available in capsules and in eye drops. Cysteamine acts to solubilize the cystine by (1) forming...
use of depigmentation agents, such as hydroquinone, tretinoin, topical cysteamine, azelaic acid, or alpha hydroxy acids. Differently from the melanotic...
niacinamide, l-ascorbic acid,[citation needed] retinoids such as tretinoin, or cysteamine hydrochloride. Hydroquinone was the most commonly prescribed hyperpigmentation...
In enzymology, a cysteamine dioxygenase (EC 1.13.11.19) is an enzyme that catalyzes the chemical reaction 2-aminoethanethiol + O2 ⇌ {\displaystyle \rightleftharpoons...
which is produced from pantothenic acid (vitamin B5) by the addition of cysteamine. Pantethine was discovered by Gene Brown, a PhD student at the time. Pantethine...
case, however other agents might work well (4% hydroquinone, 5% topical cysteamine, 10% topical ascorbic acid). Freckle List of skin diseases Mole Skin disease...
lightening in melasma by decreasing melanogenesis in epidermal melanocytes. Cysteamine hydrochloride (5%) over-the-counter Mechanism of action seems to involve...
into cysteamine and RS-cysteamine mixed disulfide by thiol-disulfide exchange. This is done by consumption of intracellular glutathione. Cysteamine is then...
resolved by treatment with cysteamine. Cysteamine acts to solubilize the cystine by (1) forming the mixed disulfide cysteine-cysteamine, which is more soluble...
phloroglucinolysis), thioglycolic acid (thioglycolysis), benzyl mercaptan or cysteamine (processes called thiolysis) leading to the formation of oligomers that...
Pantetheine is the cysteamine amide analog of pantothenic acid (vitamin B5). The dimer of this compound, pantethine is more commonly known, and is considered...
available or under research, including azelaic acid, kojic acid, retinoids, cysteamine, topical steroids, glycolic acid, and other substances. One of these,...
phloroglucinolysis), thioglycolic acid (thioglycolysis), benzyl mercaptan or cysteamine (processes called thiolysis) leading to the formation of oligomers that...
can be considered a thio analog of morpholine. It can be prepared from cysteamine and vinyl chloride: H2NCH2CH2SH + CH2=CHCl → HN(CH2)4S + HCl International...
Membrane electrode assembly, part of a PEM fuel cell Mercaptoethylamine-2 or cysteamine, an organic chemical compound Monoethanolamine, an organic chemical compound...
called thiolysis), thioglycolic acid (reaction called thioglycolysis) or cysteamine. These techniques are generally called depolymerisation and give information...
antibiotic penicillin. Thiazolidine is prepared by the condensation of cysteamine and formaldehyde. Other thiazolidines may be synthesized by similar condensations...
jtemb.2016.06.011. PMC 5141684. PMID 27908425. Schipper, HM (1993). "Cysteamine gliopathy in situ: a cellular stress model for the biogenesis of astrocytic...
difficult to determine with sufficient certainty in clinical practice. Cysteamine and methionine have also been used to prevent hepatotoxicity, although...
1909. 2-Thiazolines are commonly prepared from 2-aminoethanethiols (e.g. cysteamine). They may also be synthesized via the Asinger reaction. Many molecules...
have been analysed through acid-catalyzed degradation in the presence of cysteamine and have a potent free radical scavenging activity. Quercus crispula -...
observed and modeled, stratospheric polar vortex disruption. 8 September Cysteamine, an antioxidant drug already approved for human use, is shown to reverse...
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