Crystal structure of human brain-type creatine kinase with ADP and creatine. PDB 3b6r.[1]
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EC no.
2.7.3.2
CAS no.
9001-15-4
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Creatine kinase (CK), also known as creatine phosphokinase (CPK) or phosphocreatine kinase, is an enzyme (EC 2.7.3.2) expressed by various tissues and cell types. CK catalyses the conversion of creatine and uses adenosine triphosphate (ATP) to create phosphocreatine (PCr) and adenosine diphosphate (ADP). This CK enzyme reaction is reversible and thus ATP can be generated from PCr and ADP.
In tissues and cells that consume ATP rapidly, especially skeletal muscle, but also brain, photoreceptor cells of the retina, hair cells of the inner ear, spermatozoa and smooth muscle, PCr serves as an energy reservoir for the rapid buffering and regeneration of ATP in situ, as well as for intracellular energy transport by the PCr shuttle or circuit.[2] Thus creatine kinase is an important enzyme in such tissues.[3]
Clinically, creatine kinase is assayed in blood tests as a marker of damage of CK-rich tissue such as in myocardial infarction (heart attack), rhabdomyolysis (severe muscle breakdown), muscular dystrophy, autoimmune myositides, and acute kidney injury.[4]
^Bong SM, Moon JH, Nam KH, Lee KS, Chi YM, Hwang KY (November 2008). "Structural studies of human brain-type creatine kinase complexed with the ADP-Mg2+-NO3- -creatine transition-state analogue complex". FEBS Letters. 582 (28): 3959–65. doi:10.1016/j.febslet.2008.10.039. PMID 18977227. S2CID 21911841.
^Wallimann T, Wyss M, Brdiczka D, Nicolay K, Eppenberger HM (January 1992). "Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the 'phosphocreatine circuit' for cellular energy homeostasis". The Biochemical Journal. 281 ( Pt 1) (1): 21–40. doi:10.1042/bj2810021. PMC 1130636. PMID 1731757.
^Wallimann T, Hemmer W (1994). "Creatine kinase in non-muscle tissues and cells". Molecular and Cellular Biochemistry. 133–134 (1): 193–220. doi:10.1007/BF01267955. eISSN 1573-4919. PMID 7808454. S2CID 10404672.
^Moghadam-Kia S, Oddis CV, Aggarwal R (January 2016). "Approach to asymptomatic creatine kinase elevation". Cleveland Clinic Journal of Medicine. 83 (1): 37–42. doi:10.3949/ccjm.83a.14120. PMC 4871266. PMID 26760521.
Creatinekinase (CK), also known as creatine phosphokinase (CPK) or phosphocreatine kinase, is an enzyme (EC 2.7.3.2) expressed by various tissues and...
using S-adenosyl methionine as the methyl donor. Creatine itself can be phosphorylated by creatinekinase to form phosphocreatine, which is used as an energy...
cells it is transformed into phosphocreatine by the enzyme complex creatinekinase. Phosphocreatine is able to donate its phosphate group to convert adenosine...
Fedosov, S. N (1994). "Creatine-creatine phosphate shuttle modeled as two-compartment system at different levels of creatinekinase activity" (PDF). Biochimica...
use creatine. Creatine phosphate (CP), or phosphocreatine (PCr), is made from ATP by the enzyme creatinekinase in a reversible reaction: Creatine + ATP...
red blood cells when examined with a microscope. Blood tests show a creatinekinase activity greater than 1,000 U/L, with severe disease being above 5...
dystrophin in muscle cells.) Creatinekinase test (checks the level of CreatineKinase proteins in the blood. CreatineKinase proteins are normally found...
lactate transporter defect, and myopathy with myalgia, increased serum creatinekinase, with or without episodic rhabdomyolysis (MMCKR) also include muscle...
Creatinekinase, mitochondrial 1B also known as CKMT1B is one of two genes which encode the ubiquitous mitochondrial creatinekinase (ubiquitous mtCK or...
frequently be made at birth through genetic testing, and elevated creatinekinase levels in the blood are indicative of the condition. While there is...
used for estimating damage to cardiac tissue, although troponin and creatinekinase tests are preferred. Reference ranges for blood tests Elevated transaminases...
to the injured tissue to send repair cells to the area. This allows creatinekinase and myoglobin to be flushed from the tissue where it travels in the...
muscle fibers, fiber-type grouping, and centralized nuclei. Serum creatinekinase (CK) levels are much higher than would be expected for a purely neurogenic...
Critical levels of other cardiac biomarkers are also relevant, such as creatinekinase. Other conditions that directly or indirectly lead to heart muscle...
elevated CK, and fishy body odour. Myopathy with myalgia, increased serum creatinekinase, with or without episodic rhabdomyolysis (MMCKR) has exercise-induced...
the diagnosis of myositis. The doctor may look for an elevation of creatinekinase in the blood, which is indicative of muscle inflammation. Certain autoantibodies...
diagnose catatonia. These lab findings include: leukocytosis, elevated creatinekinase, low serum iron. The signs and symptoms of malignant catatonia overlap...
Creatinekinase S-type, mitochondrial is an enzyme that in humans is encoded by the CKMT2 gene. Mitochondrial creatinekinase (MtCK) is responsible for...
muscle contraction by ATPase) H+ + ADP + CP → ATP + Creatine (Mg2+ assisted, catalyzed by creatinekinase, ATP is used again in the above reaction for continued...
coronary reperfusion after thrombolysis with a model combining myoglobin, creatinekinase-MB, and clinical variables. TAMI-7 Study Group. Thrombolysis and Angioplasty...
PMID 18218779. Sahlin, Kent; Harris, Roger C. (2011-05-01). "The creatinekinase reaction: a simple reaction with functional complexity". Amino Acids...
would show normal or near normal levels of mtDNA. A blood test for creatinekinase (CK) can be done under normal circumstances to test for signs of tissue...
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