dentate gyrus of hippocampal formation granule cell
otolith organ
utricle
cerebellar cortex
lobe of cerebellum
zygote
substantia nigra
neural layer of retina
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
SH3 domain binding
protein binding
synaptic receptor adaptor activity
ionotropic glutamate receptor binding
signaling receptor complex adaptor activity
Cellular component
cytoplasm
postsynaptic membrane
cell projection
membrane
postsynaptic density
neurofilament
photoreceptor inner segment
growth cone
plasma membrane
dendritic spine
photoreceptor outer segment
synapse
brush border membrane
cell junction
neuronal cell body
apical plasma membrane
ciliary membrane
neuron projection
ionotropic glutamate receptor complex
cytosol
cellular component
dendrite
neuron spine
Biological process
learning
vocalization behavior
adult behavior
long-term depression
social behavior
synapse assembly
long-term potentiation
brain morphogenesis
synaptic assembly at neuromuscular junction
positive regulation of synaptic transmission, glutamatergic
dendritic spine morphogenesis
positive regulation of dendritic spine development
postsynaptic density assembly
regulation of AMPA receptor activity
positive regulation of excitatory postsynaptic potential
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
22941
210274
Ensembl
ENSG00000162105
ENSMUSG00000037541
UniProt
Q9UPX8
Q80Z38
RefSeq (mRNA)
NM_012309 NM_133266 NM_001379226
NM_001081370 NM_001113373
RefSeq (protein)
NP_036441 NP_573573 NP_001366155
NP_001074839 NP_001106844
Location (UCSC)
Chr 11: 70.47 – 71.25 Mb
Chr 7: 143.56 – 143.98 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
SH3 and multiple ankyrin repeat domains protein 2 is a protein that in humans is encoded by the SHANK2 gene.[5][6] Two alternative splice variants, encoding distinct isoforms, are reported. Additional splice variants exist but their full-length nature has not been determined.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000162105 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000037541 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Lim S, Naisbitt S, Yoon J, Hwang JI, Suh PG, Sheng M, Kim E (October 1999). "Characterization of the Shank family of synaptic proteins. Multiple genes, alternative splicing, and differential expression in brain and development". The Journal of Biological Chemistry. 274 (41): 29510–8. doi:10.1074/jbc.274.41.29510. PMID 10506216.
repeat domains protein 2 is a protein that in humans is encoded by the SHANK2 gene. Two alternative splice variants, encoding distinct isoforms, are reported...
genus Tringa Shankh, a quantity in the Indian numbering system SHANK1, SHANK2, and SHANK3, types of protein Bud Shank, an American saxophonist Christopher...
Hartmut; Sprengel, Rolf; Scherer, Stephen W. (2010-06-01). "Mutations in the SHANK2 synaptic scaffolding gene in autism spectrum disorder and mental retardation"...
receptors and autism was also identified via the structural protein ProSAP1 SHANK2 and potentially ProSAP2 SHANK3. The study authors concluded that the study...
disorders defined by genetics. One gene that has been linked to autism is SHANK2. Mutations in this gene act in a dominant fashion. Mutations in this gene...
protein called guanylate kinase-associated protein (GKAP). GKAP binds to the SHANK2 and PSD-95 proteins, facilitating the assembly of the post-synaptic density...
SHANK2 is located on chromosome 11, and SHANK3 on chromosome 22. The locus of SHANK1, in particular, is less studied in relation to ASD than SHANK2 and...
activated via DHPH RhoGEF domain. The neuronal synapse adaptors SHANK1, SHANK2, and SHANK3 via PDZ Scribble via PDZ SNX27 via PDZ Rho family of GTPases...
channels. As with many other synaptic genes, including its binding partner Shank2, DLGAP2 has been shown to be associated with Autism. ENSG00000282152, ENSG00000282318...
cognitive functions. Somatostatin receptor 2 has been shown to interact with SHANK2. The somatostatin hormone itself can negatively affect the uptake of hormones...
State University". Eunjoon, Kim (2012). "Autistic-like social behavior in Shank2-mutant mice improved by restoring NMDA receptor function". Nature. 486 (7402):...
has not been determined. DNM2 has been shown to interact with: SHANK1, SHANK2, and SNX9. Mutations in this gene have been associated to cases of acute...
Global Information
