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Medical condition
Combined hyperlipidemia
Other names
Multiple-type hyperlipoproteinemia
Combined hyperlipidemia is inherited in an autosomal dominant manner.
Specialty
Endocrinology
Combined hyperlipidemia (or -aemia) is a commonly occurring form of hypercholesterolemia (elevated cholesterol levels) characterised by increased LDL and triglyceride concentrations, often accompanied by decreased HDL.[1]: 534 On lipoprotein electrophoresis (a test now rarely performed) it shows as a hyperlipoproteinemia type IIB. It is the most commonly inherited lipid disorder, occurring in around one in 200 persons. In fact, almost one in five individuals who develop coronary heart disease before the age of 60 have this disorder.
The elevated triglyceride levels (>5 mmol/L) are generally due to an increase in very low density lipoprotein (VLDL), a class of lipoproteins prone to cause atherosclerosis.
^James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 978-0-7216-2921-6.
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Combinedhyperlipidemia (or -aemia) is a commonly occurring form of hypercholesterolemia (elevated cholesterol levels) characterised by increased LDL...
Hyperlipidemia is abnormally high levels of any or all lipids (e.g. fats, triglycerides, cholesterol, phospholipids) or lipoproteins in the blood. The...
"Effectiveness and tolerability of simvastatin plus fenofibrate for combinedhyperlipidemia (The SAFARI trial)". The American Journal of Cardiology. 95 (4):...
elements and E-box motifs. This gene has been linked to familial combinedhyperlipidemia (FCHL). Two transcript variants encoding distinct isoforms have...
Type IV) Primary dysbetalipoproteinemia (Fredrickson Type III) Combinedhyperlipidemia Primary prevention of heart attack, stroke, and need for revascularization...
predisposition; some forms of familial hyperlipidemia such as familial combinedhyperlipidemia i.e. Type II hyperlipidemia Lipoprotein lipase deficiency - Deficiency...
approved for medical use in 1978. Bezafibrate improves markers of combinedhyperlipidemia, effectively reducing LDL and triglycerides and improving HDL levels...
cholesterol, such as combinedhyperlipidemia due to metabolic syndrome. FH needs to be distinguished from familial combinedhyperlipidemia and polygenic hypercholesterolemia...
several chromosomal regions, including regions linked to familial combinedhyperlipidemia, was found. These findings suggest that there are many genetic...
DB, de Jong P, Lusis AJ (Jan 2002). "Positional cloning of the combinedhyperlipidemia gene Hyplip1". Nature Genetics. 30 (1): 110–6. doi:10.1038/ng811...
novel apolipoprotein A-IV variants in individuals with familial combinedhyperlipidemia and diminished levels of lipoprotein lipase activity". Hum. Mutat...
Sweden FC Hjørring, in Denmark FC Homburg, in Germany Familial combinedhyperlipidemia Felipe Calderón Hinojosa (born 1962), President of Mexico 2006–2012...
(2013). "Hibiscus sabdariffa L. In the treatment of hypertension and hyperlipidemia: A comprehensive review of animal and human studies". Fitoterapia. 85:...
used. Doses may not need to be as high as those previously used for hyperlipidemia. Many patients find them hard to tolerate, as although the diarrhea...
birth or as a disease of adults characterized by edema, fatigue, and hyperlipidemia. The reason for this heterogeneity of presentation is not well understood...
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such as male gender of <60 years old. Hyperglycemia, high blood sugar Hyperlipidemia, high cholesterol and triglycerides Headache Nausea/vomiting Photosensitivity...
tobacco products is associated with increased cardiovascular risk, hyperlipidemia, and increased insulin resistance, there is insufficient evidence to...
decrease in circulating blood and causes sodium and water retention. Hyperlipidemia is thought to be a result of the increased activity of the liver.: 549 ...
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