−16.3 °C (2.7 °F; 256.8 K) hydrate melts at 43–50 °C[1]
Boiling point
85 to 85.5 °C (185.0 to 185.9 °F; 358.1 to 358.6 K)
Solubility in water
soluble[1]
Solubility
organic solvents
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
alkylating agent
GHS labelling:
Pictograms
Signal word
Danger
Hazard statements
H301, H311, H314, H330, H351, H400
Flash point
87.7 °C (189.9 °F) (closed cup)
Lethal dose or concentration (LD, LC):
LD50 (median dose)
89 mg/kg (oral, rat) 82 mg/kg (oral, mouse)[3]
LC50 (median concentration)
200 ppm (rat, 1 hr)[4]
NIOSH (US health exposure limits):
PEL (Permissible)
C 1 ppm (3 mg/m3)[2]
REL (Recommended)
C 1 ppm (3 mg/m3)[2]
IDLH (Immediate danger)
45 ppm[2]
Related compounds
Related compounds
2-chloroethanol, Chloroacetic acid
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
Chemical compound
Chloroacetaldehyde is an organic compound with the formula ClCH2CHO. Like some related compounds, it is highly electrophilic reagent and a potentially dangerous alkylating agent. The compound is not normally encountered in the anhydrous form, but rather as the hemiacetal (ClCH2CH(OH))2O.
Chloroacetaldehyde is a metabolite of the antineoplastic ifosfamide and believed to be responsible for some of the toxicity observed with ifosfamide.
^ abcThe Merck index. S Budavari, M O'Neil, A Smith (12 ed.). Merck. 1996. p. 2108. ISBN 9780911910124.{{cite book}}: CS1 maint: others (link)
^ abcNIOSH Pocket Guide to Chemical Hazards. "#0118". National Institute for Occupational Safety and Health (NIOSH).
^"Chloroacetaldehyde". National Institute for Occupational Safety and Health. 4 December 2014. Retrieved 20 February 2015.
^"Chloroacetaldehyde". Immediately Dangerous to Life or Health Concentrations (IDLH). National Institute for Occupational Safety and Health (NIOSH).
and 14 Related for: Chloroacetaldehyde information
Chloroacetaldehyde is an organic compound with the formula ClCH2CHO. Like some related compounds, it is highly electrophilic reagent and a potentially...
Kopp E, McKusick BC, Röderer G, Bosch A, Fleischmann G (2007). "Chloroacetaldehydes". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH...
with a LC50 for 4-hour exposure of 440 mg/m3. Chloral cyanohydrin Chloroacetaldehyde Dichloroacetaldehyde Fluoral Bromal Iodal Luknitskii, F. I. (1975)...
oxide and chloroacetaldehyde. The former is produced by the action of cytochrome P-450 on VC. Both chloroethylene oxide and chloroacetaldehyde are alkylating...
neuropsychiatric toxicity in 1994. A toxic metabolite of ifosfamide, chloroacetaldehyde (CAA), disrupts the mitochondrial respiratory chain, leading to an...
people receiving the agent. The reaction is probably mediated by chloroacetaldehyde, one of the breakdown products of the ifosfamide molecule, which has...
is significant because it causes DNA alkylation. It isomerizes to chloroacetaldehyde, which modifies adenosine residues by conversion to 1,N6-ethenodeoxyadenosine...
78.50 g/mol, exact mass: 77.9872 u) may refer to: Acetyl chloride Chloroacetaldehyde Chloroethylene oxide This set index page lists chemical structure...
the chlorination of ethylene carbonate in substance or solution, 2-chloroacetaldehyde, polychlorinated ethylene carbonate and chlorinated ring-opening products...
been flipped out by cytosine-C5 and adenine-N6 methyltransferases. Chloroacetaldehyde is used to detect cytosine residues flipped out by the HhaI DNA cytosine-5...
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