Chloracne in this herbicide production worker involved almost every follicular orifice on his face and neck with comedones, papules and cystlike lesions.
Specialty
Dermatology
Chloracne is an acneiform eruption of blackheads, cysts, and pustules associated with exposure to certain halogenated aromatic compounds, such as chlorinated dioxins and dibenzofurans.[1] The lesions are most frequently found on the cheeks, behind the ears, in the armpits and groin region.
The condition was first described in German industrial workers in 1897 by Siegfried Bettmann,[2] and was initially believed to be caused by exposure to chlorine (hence the name "chloracne"). It was only in the mid-1950s that chloracne was associated with aromatic hydrocarbons.[3] The substances that may cause chloracne are now collectively known as chloracnegens.
Chloracne is particularly linked to toxic exposure to dioxins (byproducts of many chemical processes, including the manufacture of herbicides such as Agent Orange)—so much so that it is considered a clinical sign of dioxin exposure. The severity and onset of chloracne may follow a typical asymptotic dose-response relationship curve.
^Plewig, Gerd; Melnik, Bodo; Chen, WenChieh (2019). "9.4.3 Acne mimicking diseases". Plewig and Kligman ́s Acne and Rosacea. Switzerland: Springer. p. 306-307. ISBN 978-3-319-49273-5.
^Siegfried Bettmann (1869–1939), University of Heidelberg
^Williams DE, Wolfe WH, Lustik MB, et al. (1995). "An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides". p. 427. A313403. Archived from the original on 2012-02-10. Retrieved 2008-08-20.
Chloracne is an acneiform eruption of blackheads, cysts, and pustules associated with exposure to certain halogenated aromatic compounds, such as chlorinated...
irritation. The accident also immediately caused 193 individuals to develop chloracne, none of whom were employed at the ICMESA plant. By the 2nd of August...
by government agents. After the illness, his face has shown signs of chloracne. British toxicologist Professor John Henry of St Mary's Hospital in London...
of dioxins in humans causes a severe form of persistent acne, known as chloracne. High occupational or accidental levels of exposures to dioxins have been...
affect human skin, because workers at its chemical plants were developing chloracne. In the study, Kligman applied about the same amount of dioxin as that...
workers in polychlorinated naphthalene (PCN) manufacturing suffering from chloracne (Teleky 1927), and by the late 1930s it was known that workers exposed...
exposed to extremely high levels of PCBs are skin conditions, such as chloracne and rashes, but these were known to be symptoms of acute systemic poisoning...
differentiate acne from skin disorders that are similar in appearance. Chloracne and occupational acne due to exposure to certain chemicals & industrial...
conditions directly related to non-Hodgkin lymphoma, soft-tissue sarcoma, chloracne, and consistent acneform diseases for military personnel who served in...
regularly. Direct skin contact results in a severe acne-like condition called chloracne. Exposure increases the risk of skin cancer, liver cancer, and brain cancer...
several adverse effects in humans, including immune and enzyme disorders, chloracne, and are classified as a possible human carcinogen. In laboratory studies...
safety threshold dosages. In many cases, excessive doses would produce chloracne, inflammatory pustules, and papules which lasted four to seven months...
symptoms of gastrointestinal disruption, neuropathy, depression, and chloracne. Regular exposure of PCNs by cable workers, assemblers, and labourers...
food chain. In addition, 193 people in the affected areas suffered from chloracne and other symptoms. The disaster lead to the Seveso Directive, which was...
production, health hazards began to be reported in workers exposed to PCNs: chloracne, severe skin rashes and liver disease that led to deaths of workers. A...
a chemist and spread dioxins over the debris. 79 employees contracted chloracne whilst cleaning up and even some of their families were affected by traces...
curative in almost all cases, but usually impractical. Contact dermatitis Chloracne List of cutaneous conditions Bolognia JL, Schaffer JV, Cerroni L (2017)...
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