Chemical ligation information

Chemical ligation is the chemoselective condensation of unprotected peptide segments enabled by the formation of a non-native bond at the ligation site...

Native Chemical Ligation (NCL) is an important extension of the chemical ligation concept for constructing a larger polypeptide chain by the covalent condensation...

molecules Chemical ligation, the chemoselective condensation of unprotected peptides In medicine, the making of a ligature (tie) Tubal ligation, a method...

fragments made by synthesis, chemical biologists can use the process of native chemical ligation. Native chemical ligation involves the coupling of a C-terminal...

traditional resin-based solid phase techniques would be better. Native chemical ligation (NCL) is a convergent synthetic strategy based on the linear coupling...

nucleophiles, giving amides: This reaction is exploited in native chemical ligation, a protocol for peptide synthesis. In a related reaction, thioesters...

segment (called an intein) is removed from a precursor protein with a ligation of C-terminal and N-terminal external proteins (called exteins) on both...

real time in living systems without cellular toxicity. A number of chemical ligation strategies have been developed that fulfill the requirements of bioorthogonality...

real time in living systems without cellular toxicity. A number of chemical ligation strategies have been developed that fulfill the requirements of bioorthogonality...

to make. Longer lengths can be accessed by using ligation approaches such as native chemical ligation, where two shorter fully deprotected synthetic peptides...

amine and a phosphine oxide byproduct. Of interest in chemical biology is the Staudinger ligation, which has been called one of the most important bioconjugation...

Protein chemical synthesis by native peptide ligation of unprotected peptide segments is an interesting complement and potential alternative to the use...

synthesized chemically by a family of methods known as peptide synthesis, which rely on organic synthesis techniques such as chemical ligation to produce...

game company Northern Coalfields, Indian coal company Native chemical ligation, a chemical way to synthesize proteins Neuronal ceroid lipofuscinosis, neurodegenerative...

Amide-Forming Ligation is a chemical reaction that is used to join two unprotected fragments in peptide synthesis. It is an alternative to the Native Chemical Ligation...

up to 300 amino acids are produced by a convergent approach using chemical ligation. An example of its use in total synthesis is the final step (photochemical...

the L-protein and the D-protein are prepared by total chemical synthesis. Native chemical ligation of unprotected peptide segments is used to prepare the...

studied the chemical foundations of the construction of recombinant RNAs, including region-specific cleavage of the RNA chain and chemical ligation of fragments...

catalyze the joining (ligation) of two molecules by forming a new chemical bond. This is typically via hydrolysis of a small pendant chemical group on one of...

in Figure 4). An example of C-termini modification is the native chemical ligation (NCL), which is the coupling between a C-terminal thioester and a...

variety of proteins have been obtained by chemical synthesis. A successful approach relies on native chemical ligation, which achieves the synthesis of proteins...

structural isomers (constitutional isomers) of chemical compounds that readily interconvert. The chemical reaction interconverting the two is called tautomerization...

libraries. A peptide chain of 10 residues in length is used in native chemical ligation with a larger recombinantly expressed protein. Residue 1: alanine...