The α-Ketoacid-Hydroxylamine (KAHA) Amide-Forming Ligation is a chemical reaction that is used to join two unprotected fragments in peptide synthesis.[1][2] It is an alternative to the Native Chemical Ligation (NCL).
KAHA Ligation was developed by Jeffrey W. Bode group at ETH Zürich (previously University of Pennsylvania).
^Bode, Jeffrey W.; Fox, Ryan M.; Baucom, Kyle D. (2006). "Chemoselective Amide Ligations by Decarboxylative Condensations ofN-Alkylhydroxylamines and α-Ketoacids". Angewandte Chemie. 118 (8): 1270–1274. doi:10.1002/ange.200503991. ISSN 0044-8249.
^Pusterla, Ivano; Bode, Jeffrey W. (2012). "The Mechanism of the α-Ketoacid-Hydroxylamine Amide-Forming Ligation". Angewandte Chemie. 124 (2): 528–531. doi:10.1002/ange.201107198. ISSN 0044-8249.
The α-Ketoacid-Hydroxylamine (KAHA) Amide-Forming Ligation is a chemical reaction that is used to join two unprotected fragments in peptide synthesis....
brackets KAHALigationLigation-independent cloning Typographic ligature forming This disambiguation page lists articles associated with the title Ligation. If...
Native Chemical Ligation (NCL) is an important extension of the chemical ligation concept for constructing a larger polypeptide chain by the covalent...