Method of microscopy which measures chemical bonding between the probe and surface
In materials science, chemical force microscopy (CFM) is a variation of atomic force microscopy (AFM) which has become a versatile tool for characterization of materials surfaces. With AFM, structural morphology is probed using simple tapping or contact modes that utilize van der Waals interactions between tip and sample to maintain a constant probe deflection amplitude (constant force mode) or maintain height while measuring tip deflection (constant height mode). CFM, on the other hand, uses chemical interactions between functionalized probe tip and sample. Choice chemistry is typically gold-coated tip and surface with R−SH thiols attached, R being the functional groups of interest. CFM enables the ability to determine the chemical nature of surfaces, irrespective of their specific morphology, and facilitates studies of basic chemical bonding enthalpy and surface energy. Typically, CFM is limited by thermal vibrations within the cantilever holding the probe. This limits force measurement resolution to ~1 pN, which is still very suitable considering weak COOH/CH3 interactions are ~20 pN per pair.[1][2] Hydrophobicity is used as the primary example throughout this consideration of CFM, but certainly any type of bonding can be probed with this method.
^Frisbie, C. D.; Rozsnyai, L. F.; Noy, A.; Wrighton, M. S.; Lieber, C. M. (1994). "Functional Group Imaging by Chemical Force Microscopy". Science. 265 (5181): 2071–4. Bibcode:1994Sci...265.2071F. doi:10.1126/science.265.5181.2071. PMID 17811409. S2CID 1192124.
^Noy, A.; Vezenov, D. V.; Lieber, C. M. (1997). "Chemical Force Microscopy". Annu. Rev. Mater. Sci. 27: 381. Bibcode:1997AnRMS..27..381N. doi:10.1146/annurev.matsci.27.1.381. S2CID 53075854.
and 24 Related for: Chemical force microscopy information
In materials science, chemicalforcemicroscopy (CFM) is a variation of atomic forcemicroscopy (AFM) which has become a versatile tool for characterization...
microscopy: optical, electron, and scanning probe microscopy, along with the emerging field of X-ray microscopy.[citation needed] Optical microscopy and...
cantilever. In a more sophisticated version of this experiment (ChemicalForceMicroscopy) the tips are covalently functionalized with the molecules of...
Magnetic forcemicroscopy (MFM) is a variety of atomic forcemicroscopy, in which a sharp magnetized tip scans a magnetic sample; the tip-sample magnetic...
invention of scanning tunneling microscopy (STM) and atomic forcemicroscopy (AFM), collectively called scanning probe microscopy (SPM) by Gerd Binnig and Heinrich...
a light microscope. Transmission electron microscopy is a major analytical method in the physical, chemical and biological sciences. TEMs find application...
Photoconductive atomic forcemicroscopy (PC-AFM) is a variant of atomic forcemicroscopy that measures photoconductivity in addition to surface forces...
resonance (SPR), electrochemical scanning tunneling microscopy (ESTM), and atomic forcemicroscopy (AFM) in the interrogation of various interfacial phenomena...
for surface forces and adhesion and their measurement using atomic forcemicroscopy". International Journal of Molecular Sciences. 13 (10): 12773–12856...
engineering and mathematics (STEM)". McKendry, Rachel Anne (1999). Chemicalforcemicroscopy. lib.cam.ac.uk (PhD thesis). University of Cambridge. OCLC 894601715...
Stimulated emission depletion (STED) microscopy is one of the techniques that make up super-resolution microscopy. It creates super-resolution images by...
materials, DNA-protein interactions, and the applications of Atomic ForceMicroscopy to biological materials. Hansma earned her bachelor's degree in chemistry...
specialized instruments. An account of the early history of scanning electron microscopy has been presented by McMullan. Although Max Knoll produced a photo with...
Jelínek, Pavel; Sugimoto, Yoshiaki (2015). "Chemical structure imaging of a single molecule by atomic forcemicroscopy at room temperature". Nature Communications...
Scanning thermal microscopy (SThM) is a type of scanning probe microscopy that maps the local temperature and thermal conductivity of an interface. The...
bilayers often require advanced techniques like electron microscopy and atomic forcemicroscopy. When phospholipids are exposed to water, they self-assemble...
X-ray diffraction, electron microscopy and tomography, such as transmission electron microscopy and atomic forcemicroscopy, as well as several types of...
optical microscopy which do not use visible light include scanning electron microscopy and transmission electron microscopy and scanning probe microscopy and...