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Chemical defenses in Cannabis information


Close up of a Cannabis plant

Cannabis (/ˈkænəbɪs/) is commonly known as marijuana or hemp and has two known strains: Cannabis sativa and Cannabis indica, both of which produce chemicals to deter herbivory. The chemical composition includes specialized terpenes and cannabinoids, mainly tetrahydrocannabinol (THC), and cannabidiol (CBD). These substances play a role in defending the plant from pathogens including insects, fungi, viruses and bacteria.[1][2] THC and CBD are stored mostly in the trichomes of the plant,[3] and can cause psychological and physical impairment in the user, via the endocannabinoid system and unique receptors.[4][5] THC increases dopamine levels in the brain, which attributes to the euphoric and relaxed feelings cannabis provides. As THC is a secondary metabolite, it poses no known effects towards plant development, growth, and reproduction. However, some studies show secondary metabolites such as cannabinoids, flavonoids, and terpenes are used as defense mechanisms against biotic and abiotic environmental stressors.[6][7][8]

  1. ^ McPartland, J. M. (2000). Hemp diseases and pests : management and biological control : an advanced treatise. Robert Connell Clarke, David Paul Watson. New York, N.Y.: CABI Pub. ISBN 0-85199-454-7. OCLC 43526760.
  2. ^ Kostanda, Elizabeth; Khatib, Soliman (2022). "Biotic stress caused by Tetranychus urticae mites elevates the quantity of secondary metabolites, cannabinoids and terpenes, in Cannabis sativa L." Industrial Crops and Products. 176: 114331. doi:10.1016/j.indcrop.2021.114331. S2CID 245271895.
  3. ^ Dolgin, Elie (2019-08-28). "The bioengineering of cannabis". Nature. 572 (7771): S5–S7. Bibcode:2019Natur.572S...5D. doi:10.1038/d41586-019-02525-4. S2CID 201669745.
  4. ^ Mackie, K. (2008). "Cannabinoid Receptors: Where They are and What They do". Journal of Neuroendocrinology. 20 (s1): 10–14. doi:10.1111/j.1365-2826.2008.01671.x. ISSN 0953-8194. PMID 18426493. S2CID 20161611.
  5. ^ Atakan, Zerrin (2012). "Cannabis, a complex plant: different compounds and different effects on individuals". Therapeutic Advances in Psychopharmacology. 2 (6): 241–254. doi:10.1177/2045125312457586. ISSN 2045-1253. PMC 3736954. PMID 23983983.
  6. ^ Park, Sang-Hyuck; Staples, S. Kyle; Gostin, Eric L.; Smith, Jeffrey P.; Vigil, Jose J.; Seifried, Dustin; Kinney, Chad; Pauli, Christopher S.; Heuvel, Brian D. Vanden (2019-07-19). "Contrasting Roles of Cannabidiol as an Insecticide and Rescuing Agent for Ethanol–induced Death in the Tobacco Hornworm Manduca sexta". Scientific Reports. 9 (1): 10481. Bibcode:2019NatSR...910481P. doi:10.1038/s41598-019-47017-7. ISSN 2045-2322. PMC 6642087. PMID 31324859.
  7. ^ Startek, Justyna B.; Voets, Thomas; Talavera, Karel (2019). "To flourish or perish: evolutionary TRiPs into the sensory biology of plant-herbivore interactions". Pflügers Archiv: European Journal of Physiology. 471 (2): 213–236. doi:10.1007/s00424-018-2205-1. ISSN 0031-6768. PMID 30229297. S2CID 52295450.
  8. ^ Booth, Judith K.; Page, Jonathan E.; Bohlmann, Jörg (2017-03-29). "Terpene synthases from Cannabis sativa". PLOS ONE. 12 (3): e0173911. Bibcode:2017PLoSO..1273911B. doi:10.1371/journal.pone.0173911. ISSN 1932-6203. PMC 5371325. PMID 28355238.

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Chemical defenses in Cannabis

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