Structure of the striatum in the basal ganglia of the brain
Caudate nucleus
Caudate nucleus (in red) shown within the brain
Transverse cut of brain (horizontal section), basal ganglia is blue
Details
Part of
dorsal striatum
Identifiers
Latin
nucleus caudatus
MeSH
D002421
NeuroNames
226
NeuroLex ID
birnlex_1373
TA98
A14.1.09.502
TA2
5561
FMA
61833
Anatomical terms of neuroanatomy
[edit on Wikidata]
The caudate nucleus is one of the structures that make up the corpus striatum, which is a component of the basal ganglia in the human brain.[1] While the caudate nucleus has long been associated with motor processes due to its role in Parkinson's disease,[2][clarification needed][3] it plays important roles in various other nonmotor functions as well, including procedural learning,[4] associative learning[5] and inhibitory control of action,[6] among other functions. The caudate is also one of the brain structures which compose the reward system and functions as part of the cortico–basal ganglia–thalamic loop.[1]
^ abYager LM, Garcia AF, Wunsch AM, Ferguson SM (August 2015). "The ins and outs of the striatum: Role in drug addiction". Neuroscience. 301: 529–541. doi:10.1016/j.neuroscience.2015.06.033. PMC 4523218. PMID 26116518.
^Malenka RC, Nestler EJ, Hyman SE (2009). Sydor A, Brown RY (eds.). Molecular Neuropharmacology: A Foundation for Clinical Neuroscience (2nd ed.). New York: McGraw-Hill Medical. pp. 147–148. ISBN 9780071481274.
^Bear, Mark F. (2016). Neuroscience : exploring the brain. Connors, Barry W.,, Paradiso, Michael A. (Fourth ed.). Philadelphia. p. 502. ISBN 9780781778176. OCLC 897825779.{{cite book}}: CS1 maint: location missing publisher (link)
^Malenka RC, Nestler EJ, Hyman SE (2009). Sydor A, Brown RY (eds.). Molecular Neuropharmacology: A Foundation for Clinical Neuroscience (2nd ed.). New York: McGraw-Hill Medical. p. 326. ISBN 9780071481274. Evidence that the caudate nucleus and putamen influence stimulus-response learning comes from lesion studies in rodents and primates and from neuroimaging studies in humans and from studies of human disease. In Parkinson disease, the dopaminergic innervation of the caudate and putamen is severely compromised by the death of dopamine neurons in the substantia nigra pars compacta (Chapter 17). Patients with Parkinson disease have normal declarative memory (unless they have a co-occurring dementia as may occur in Lewy body disease.) However, they have marked impairments of stimulus-response learning. Patients with Parkinson disease or other basal ganglia disorders such as Huntington disease (in which caudate neurons themselves are damaged) have deficits in other procedural learning tasks, such as the acquisition of new motor programs.
^Anderson BA, Kuwabara H, Wong DF, Roberts J, Rahmim A, Brašić JR, Courtney SM (August 2017). "Linking dopaminergic reward signals to the development of attentional bias: A positron emission tomographic study". NeuroImage. 157: 27–33. doi:10.1016/j.neuroimage.2017.05.062. PMC 5600829. PMID 28572059.
^Malenka RC, Nestler EJ, Hyman SE (2009). Sydor A, Brown RY (eds.). Molecular Neuropharmacology: A Foundation for Clinical Neuroscience (2nd ed.). New York: McGraw-Hill Medical. p. 321. ISBN 9780071481274. Functional neuroimaging in humans demonstrates activation of the prefrontal cortex and caudate nucleus (part of the striatum) in tasks that demand inhibitory control of behavior.
The caudatenucleus is one of the structures that make up the corpus striatum, which is a component of the basal ganglia in the human brain. While the...
striatum is made up of the caudatenucleus and the lentiform nucleus. However, some authors believe it is made up of caudatenucleus, putamen, and ventral...
striatum, consisting of both the dorsal striatum (caudatenucleus and putamen) and the ventral striatum (nucleus accumbens and olfactory tubercle), the globus...
lentiform nucleus is a large, lens-shaped mass of gray matter just lateral to the internal capsule. It forms part of the basal ganglia. With the caudate nucleus...
located at the base of the forebrain (telencephalon). The putamen and caudatenucleus together form the dorsal striatum. It is also one of the structures...
brain. It carries information past the basal ganglia, separating the caudatenucleus and the thalamus from the putamen and the globus pallidus. The internal...
stimulation of curious or information-seeking tendencies as well. The caudatenucleus is a region of the brain that is highly responsive to dopamine, and...
compacta (SNc) in the midbrain with the dorsal striatum (i.e., the caudatenucleus and putamen) in the forebrain. It is one of the four major dopamine...
of the ventricle is the putamen, which emerges from the head of the caudatenucleus, and sits above the tapetum; a small number of further connections...
contralateral to the movements as well as the globus pallidus and caudatenucleus. While the hyperglycemia itself is not the cause of the hemiballistic...
neuroimaging in humans demonstrates activation of the prefrontal cortex and caudatenucleus (part of the striatum) in tasks that demand inhibitory control of behavior...
solely sufficient for executive functions; for example, the caudatenucleus and subthalamic nucleus also have a role in mediating inhibitory control. Cognitive...
infants, fMRIs show increased brain activity in the nucleus accumbens and adjacent caudatenucleus, proportionate to the degree to which the women find...
the thalamus, parts of the basal ganglia (specifically, the dorsal caudatenucleus), the hippocampus, and primary and secondary association areas of neocortex...
amygdaloid body, the medial mammillary, the nucleus, the habenular nuclei, the hippocampus and the caudatenucleus. Gonadectomy is used to treat aggressive...
StPD may also have decreased volumes of grey or white matter in their caudatenucleus, which leads to difficulties in speech. People with StPD likely have...
striatum consists of the nucleus accumbens and the olfactory tubercle whereas the dorsal striatum consists of the caudatenucleus and the putamen. The putamen...
the caudatenucleus is involved in degenerative diseases of the central nervous system such as Huntington disease. In a case study of 32 acute caudate stroke...
chills are accompanied by rewarding dopamine release in the caudatenucleus and nucleus accumbens in the striatum18. Therefore, the experience of chills...
arise from this segment as well as the AComm, which irrigates the caudatenucleus and the anterior limb of the internal capsule A2 extends from the AComm...
lesions to the posterior temporal region of the brain, the head of the caudatenucleus, or both. Examples These errors can be semantic, in which the meaning...
the use of inhibitory control. The prefrontal cortex, caudatenucleus, and subthalamic nucleus are known to regulate inhibitory control cognition. Inhibitory...
cingulate cortex, parietal cortex, cerebellum, and nucleus accumbens. The prefrontal cortex, caudatenucleus, and anterior cingulate cortex are among the most...
thalamostriate vein, marking a line of separation between the thalamus and the caudatenucleus as seen upon gross dissection of the ventricles of the brain, viewed...
gets altered. General cortical atrophy occurs in aging and e.g. the caudatenucleus volume appears to decrease.[further explanation needed] There is converging...