oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
metal ion binding
vitamin D3 25-hydroxylase activity
cholesterol 26-hydroxylase activity
cholestanetriol 26-monooxygenase activity
Cellular component
mitochondrial matrix
membrane
mitochondrial membranes
mitochondrion
mitochondrial inner membrane
Biological process
sterol metabolic process
bile acid biosynthetic process
cholesterol catabolic process
calcitriol biosynthetic process from calciol
lipid metabolism
steroid biosynthetic process
steroid metabolic process
cholesterol metabolic process
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
1593
104086
Ensembl
ENSG00000135929
ENSMUSG00000026170
UniProt
Q02318
Q9DBG1
RefSeq (mRNA)
NM_000784
NM_024264
RefSeq (protein)
NP_000775
NP_077226
Location (UCSC)
Chr 2: 218.78 – 218.82 Mb
Chr 1: 74.75 – 74.78 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
CYP27A1 is a gene encoding a cytochrome P450 oxidase, and is commonly known as sterol 27-hydroxylase. This enzyme is located in many different tissues where it is found within the mitochondria. It is most prominently involved in the biosynthesis of bile acids.
^ abcGRCh38: Ensembl release 89: ENSG00000135929 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000026170 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
CYP27A1 is a gene encoding a cytochrome P450 oxidase, and is commonly known as sterol 27-hydroxylase. This enzyme is located in many different tissues...
tuberous xanthomas.[citation needed] CTX is associated with mutations in the CYP27A1 gene, located on chromosome 2q33-qter. The disorder is inherited in an...
sterol 27-hydroxylase (CYP27A1), but vitamin D2 cannot. Ergocalciferol can be directly hydroxylated at position 24 by CYP27A1. This hydroxylation also...
mitochondrial sterol 27-hydroxylase (CYP27A1), expressed in liver, and also in macrophages and other tissues. CYP27A1 contributes significantly to total...
receptor. Unlike cholecalciferol, 25-hydroxylation is not performed by CYP27A1 for ergocalciferol. Ergocalciferol and metabolites have lower affinity...
CYP2R1, present in microsomes, although other enzymes such as mitochondrial CYP27A1 can contribute. Variations in the expression and activity of CYP2R1, such...
active form by two hydroxylations: the first in the liver, by CYP2R1 or CYP27A1, to form 25-hydroxycholecalciferol (calcifediol, 25-OH vitamin D3). The...
150 mg/day. It has also been identified in vitro as a strong inhibitor of CYP27A1 (cholesterol 27-hydroxylase) and as an inhibitor of CYP46A1 (cholesterol...
is also possessed by some other cytochrome P450 enzymes, in particular CYP27A1, which is found in mitochondria. CYP2R1 is a member of the cytochrome P450...
P450 (CYP) enzymes to become active and bind to the VDR. Specifically, CYP27A1, CYP27B1, and CYP2R1 are involved in the activation of vitamin D, while...
and mitochondrial vitamin D3 25-hydroxylases (CYP2D25 and CYP27A1): a novel reaction by CYP27A1". Biochimica et Biophysica Acta (BBA) - Molecular and Cell...
Bicalutamide has been identified as a strong CYP27A1 (cholesterol 27-hydroxylase) inhibitor in vitro. CYP27A1 converts cholesterol into 27-hydroxycholesterol...
membrane of mitochondria(IMM). There are three members in the human genome, CYP27A1, CYP27B1 and CYP27C1, and an ortholog CYP27F1 in sea urchins, Strongylocentrotus...
Global Information
