Paternally-expressed gene 3 protein is a protein that in humans is encoded by the PEG3 gene.[5][6] PEG3 is an imprinted gene expressed exclusively from the paternal allele and plays important roles in controlling fetal growth rates and nurturing behaviors as has potential roles in mammalian reproduction.[7] PEG3 is a transcription factor that binds to DNA [11-13] via the sequence motif AGTnnCnnnTGGCT, which it binds to using multiple Kruppel-like factors. It also regulate the expression of Pgm2l1 through the binding of the motif.[8]
^ abcGRCh38: Ensembl release 89: ENSG00000198300 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000002265 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kim J, Ashworth L, Branscomb E, Stubbs L (August 1997). "The human homolog of a mouse-imprinted gene, Peg3, maps to a zinc finger gene-rich region of human chromosome 19q13.4". Genome Res. 7 (5): 532–40. doi:10.1101/gr.7.5.532. PMC 310658. PMID 9149948.
^"Entrez Gene: PEG3 paternally expressed 3".
^Michelle M. Thiaville; Jennifer M. Huang; Hana Kim; Muhammad B. Ekram; Arundhati Bakshi; Tae-Young Roh; Joomyeong Kim (December 31, 2013). "Peg3 Mutational Effects on Reproduction and Placenta-Specific Gene Families". PLOS ONE. 8 (12): e83359. Bibcode:2013PLoSO...883359K. doi:10.1371/journal.pone.0083359. PMC 3877027. PMID 24391757.
^Thiaville MM, Huang JM, Kim H, Ekram MB, Roh TY, Kim J (January 2013). "DNA-binding motif and target genes of the imprinted transcription factor PEG3". Gene. 512 (2): 314–320. doi:10.1016/j.gene.2012.10.005. PMC 3513644. PMID 23078764.
Paternally-expressed gene 3 protein is a protein that in humans is encoded by the PEG3 gene. PEG3 is an imprinted gene expressed exclusively from the paternal allele...
lineage. Studies have shown that PEG3 and Nespas are downstream targets of Rex1. Rex1 can control the expression of Peg3 via epigenetic changes. YY1 has...
ENSG00000139515 Homeodomain Known motif – High-throughput in vitro [689] BTAATKR PEG3 ENSG00000198300 C2H2 ZF Likely sequence specific TF according to literature...
the mono-allelic expression of the seven imprinted genes in the cluster: Peg3, Usp29, Zfp264, APeg3 (paternally expressed) and Zim1, Zim2, Zim3 (maternally...
Tassan JP (October 2002). "Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation". Oncogene...
Choo, J. H.; Stubbs, L. (2007). "Genomic organization and imprinting of the Peg3 domain in bovine". Genomics. 90 (1): 85–92. doi:10.1016/j.ygeno.2007.03.012...
parent-infant coadaptation to improve infant survival. Paternally expressed 3 (PEG3) is a gene for which this hypothesis may apply. Others have approached their...
to hypoxia. SIAH2 has been shown to interact with PEG10, Synaptophysin, PEG3 and VAV1. GRCh38: Ensembl release 89: ENSG00000181788 – Ensembl, May 2017...
receptor) which leads to increased levels of tumor suppressor gene called PEG3. Other angiogenic growth factors that decorin inhibits are angiopoietin,...
Jean-Pierre (October 2002). "Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation". Oncogene...
cells in small samples using flow cytometry. Biotin-PEG2-maleimide Biotin-PEG3-amine Biotin-PEG4-NHS "EZ-Link™ Amine-PEG2-Biotin". Bronfman, F.C.; et al...
WT & Keverne EB (2009) Paternal influence on female behavior: The role of Peg3 in exploration, olfaction and neuroendocrine regulation of maternal behavior...
evolution of two Kruppel-type zinc-finger genes, ZIM3 and ZNF264, located in the PEG3/USP29 imprinted domain". Genomics. 77 (1–2): 91–8. doi:10.1006/geno.2001...
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