regulation of cyclin-dependent protein serine/threonine kinase activity
cellular response to UV
protein dephosphorylation
regulation of cell cycle
cell division
G2/M transition of mitotic cell cycle
cell cycle
response to radiation
peptidyl-tyrosine dephosphorylation
cell population proliferation
protein deubiquitination
positive regulation of cell cycle G2/M phase transition
G1/S transition of mitotic cell cycle
positive regulation of G2/M transition of mitotic cell cycle
positive regulation of mitotic cell cycle
positive regulation of G2/MI transition of meiotic cell cycle
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
993
12530
Ensembl
ENSG00000164045
ENSMUSG00000032477
UniProt
P30304
P48964
RefSeq (mRNA)
NM_001789 NM_201567
NM_007658
RefSeq (protein)
NP_001780 NP_963861
NP_031684
Location (UCSC)
Chr 3: 48.16 – 48.19 Mb
Chr 9: 109.7 – 109.72 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
M-phase inducer phosphatase 1 also known as dual specificity phosphatase Cdc25A is a protein that in humans is encoded by the cell division cycle 25 homolog A (CDC25A) gene.
^ abcGRCh38: Ensembl release 89: ENSG00000164045 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000032477 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
specificity phosphatase Cdc25A is a protein that in humans is encoded by the cell division cycle 25 homolog A (CDC25A) gene. CDC25A is a member of the CDC25...
can be reactivated after dephosphorylation by Cdc25. The Cdc25 enzymes Cdc25A-C are known to control the transitions from G1 to S phase and G2 to M phase...
phosphatase activity via activating the intermediate kinase PLK1, and stabilizes Cdc25A. Thus, CDK1 forms a positive feedback loop with Cdc25 and a double negative...
which in turn phosphorylate the phosphatase Cdc25A, thus marking it for ubiquitination and degradation. As Cdc25A activates the previously mentioned cyclin...
active ATR and ATM stalls cell cycle progression by promoting degradation of CDC25A, a phosphatase that removes inhibitory phosphate residues from CDKs. Homologous...
indole-3-carbinol effects on breast carcinogenesis involves induction of Cdc25A degradation". Cancer Prevention Research. 3 (7): 818–828. doi:10.1158/1940-6207...
viable after the CDC25B (and CDC25C) genes are "knocked out", but removal of CDC25A results in non-viable cells. Indirubin has not been shown to prevent or...
specificity. The third class of PTPs contains three cell cycle regulators, CDC25A, CDC25B and CDC25C, which dephosphorylate CDKs at their N-terminal, a reaction...
related families in #Structure and mechanism): M-phase inducer phosphatase: CDC25A; CDC25B; CDC25C; Dual specificity protein phosphatase: DUSP; DUSP1; DUSP2;...
transition in human embryonic stem cells through direct binding of CDK6 and CDC25A". The Journal of Cell Biology. 184 (1): 67–82. doi:10.1083/jcb.200801009...
Xiaodong Zhang; et al. (13 October 2009). "microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells". Cancer Research. 69 (20):...
division cycle 25A (CDC25A) is a phosphatase that removes an inhibitory phosphate group from CDK2. While ubiquitination would mark CDC25A for degradation...
sites is done by the Cdc25 family. In vertebrates, the Cdc25 enzymes are Cdc25A which controls the checkpoints of G1/S and G2/M as well as Cdc25B and Cdc25C...
PMC 4666830. PMID 26028036. Shen, Tao; Huang, Shile (2012). "The Role of Cdc25A in the Regulation of Cell Proliferation and Apoptosis". Anti-Cancer Agents...
well as post-transcriptional. ASK1 has been shown to interact with: C-Raf, CDC25A, DAXX, DUSP19, EIF2AK2, GADD45B, HSPA1A, MAP2K6, MAP3K7 and MAPK8IP3, PDCD6...
been shown to degrade Pim-1. PIM1 has been shown to interact with: CBX3, CDC25A, Heat shock protein 90kDa alpha (cytosolic), member A1, NFATC1, Nuclear...
families of cell cycle kinase inhibitors. TGFb inhibits the transcription of Cdc25A, a phosphatase that activates the cell cycle kinases, and growth factor...
βTrCP keeps CDK1 in check by promoting the degradation of the phosphatase CDC25A, whereas in G2, βTrCP contributes to CDK1 activation by targeting the kinase...
D, Dorrello NV, Hershko A, Pagano M, Draetta GF (2003). "Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage". Nature. 426...
Sexl V, Diehl JA, Sherr CJ, et al. (1999). "A rate limiting function of cdc25A for S phase entry inversely correlates with tyrosine dephosphorylation of...
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