negative regulation of interferon-gamma production
positive regulation of protein kinase B signaling
negative regulation of MDA-5 signaling pathway
regulation of transcription, DNA-templated
adaptive immune response
ribosome biogenesis
negative regulation of defense response to virus
immune system process
mRNA processing
negative regulation of transcription by RNA polymerase II
transcription, DNA-templated
positive regulation of trophoblast cell migration
positive regulation of substrate adhesion-dependent cell spreading
mature ribosome assembly
negative regulation of mRNA splicing, via spliceosome
immune response
RNA splicing
positive regulation of neutrophil chemotaxis
complement activation, classical pathway
positive regulation of apoptotic process
phosphatidylinositol 3-kinase signaling
innate immune response
viral process
positive regulation of dendritic cell chemotaxis
regulation of complement activation
negative regulation of RIG-I signaling pathway
positive regulation of cell adhesion
negative regulation of interleukin-12 production
apoptotic process
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
708
12261
Ensembl
ENSG00000108561
ENSMUSG00000018446
UniProt
Q07021
O35658 Q8R5L1
RefSeq (mRNA)
NM_001212
NM_007573
RefSeq (protein)
NP_001203
NP_031599
Location (UCSC)
Chr 17: 5.43 – 5.45 Mb
Chr 11: 70.87 – 70.87 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Complement component 1 Q subcomponent-binding protein, mitochondrial is a protein that in humans is encoded by the C1QBP gene.[5][6][7]
The human complement subcomponent C1q associates with C1r and C1s in order to yield the first component of the serum complement system. The protein encoded by this gene is known to bind to the globular heads of C1q molecules and inhibit C1 activation. This protein has also been identified as the p32 subunit of pre-mRNA splicing factor SF2, as well as a hyaluronic acid-binding protein.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000108561 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000018446 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Deb TB, Datta K (March 1996). "Molecular cloning of human fibroblast hyaluronic acid-binding protein confirms its identity with P-32, a protein co-purified with splicing factor SF2. Hyaluronic acid-binding protein as P-32 protein, co-purified with splicing factor SF2". J Biol Chem. 271 (4): 2206–12. doi:10.1074/jbc.271.4.2206. PMID 8567680.
^Ghebrehiwet B, Lim BL, Peerschke EI, Willis AC, Reid KB (June 1994). "Isolation, cDNA cloning, and overexpression of a 33-kD cell surface glycoprotein that binds to the globular "heads" of C1q". J Exp Med. 179 (6): 1809–21. doi:10.1084/jem.179.6.1809. PMC 2191527. PMID 8195709.
subcomponent-binding protein, mitochondrial is a protein that in humans is encoded by the C1QBP gene. The human complement subcomponent C1q associates with C1r and C1s...
and other mitochondrial diseases. CHCHD10 has been known to interact with C1QBP, CLPX, FAF1, RNASEH1, ZNF444, KLF13, and other proteins. "Entrez Gene:...
of hyaladherins lacking a Link module; these include the receptor RHAMM, C1QBP (HABP1) and HABP2. The primary roles of hyaladherins are cell adhesion,...
isoforms described for this gene. BAT2 has been shown to interact with: C1QBP, EIF3S6, HNRNPA1, IFT88, IMMT, and UBAP2L. ENSG00000206427, ENSG00000231825...
overexpression of isozyme PKCα. PKC alpha has been shown to interact with: C1QBP, CD29, EGFR, FSCN1, and OGG1. GRCh38: Ensembl release 89: ENSG00000154229...
Protein kinase D1 has been shown to interact with: Bruton's tyrosine kinase, C1QBP, Centaurin, alpha 1, Metallothionein 2A, and YWHAQ. GRCh38: Ensembl release...