The Buehler test is an in vivo test to screen for substances that cause human skin sensitisation (i.e. allergens). It was first proposed by Edwin Vernon Buehler in 1965[1] and further explained in 1980.[2]
It is a non-adjuvant test. In the test, guinea pigs are exposed to a high dose of the substance. They are then given a challenge dose, which is the highest dose that does not cause irritation.[3]
The test has been largely superseded by the murine local lymph node assay.[citation needed]
^Buehler E.V. (1965). Delayed contact hypersensitivity in the guinea pig. Archives of Dermatology, 91, 171
^Ritz, H. L.; Buehler, E. V. (1980). "Procedure for conducting the guinea pig assay". In Drill, V. A. and; Lazar, P. (eds.). Current Concepts in Dermatology. New York: Academic Press. pp. 25–40.
^OECD (1992-07-17). "Test No. 406: Skin Sensitisation". OECD Guidelines for the Testing of Chemicals, Section 4. OECD Publishing. doi:10.1787/9789264070660-en. Retrieved 2012-02-17.
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