Significant economic disease of cattle caused by two species of Pestivirus
Bovine viral diarrhea
Immunofluorescence image of BVDV (CP7 type). Nuclei are stained blue with DAPI. The replication complexes of the viruses are marked red by NS3 protein binding antibodies
Scientific classification
(unranked):
Virus
Realm:
Riboviria
Kingdom:
Orthornavirae
Phylum:
Kitrinoviricota
Class:
Flasuviricetes
Order:
Amarillovirales
Family:
Flaviviridae
Genus:
Pestivirus
Groups included
Pestivirus A (formerly Bovine viral diarrhea virus 1)
Pestivirus B (formerly Bovine viral diarrhea virus 2)
Cladistically included but traditionally excluded taxa
Pestivirus C
Pestivirus D
Pestivirus E
Pestivirus F
Pestivirus G
Pestivirus H
Pestivirus I
Pestivirus J
Pestivirus K
Bovine viral diarrhea (BVD), bovine viral diarrhoea (UK English) or mucosal disease, previously referred to as bovine virus diarrhea (BVD), is an economically significant disease of cattle that is found in the majority of countries throughout the world.[1] Worldwide reviews of the economically assessed production losses and intervention programs (e.g. eradication programs, vaccination strategies and biosecurity measures) incurred by BVD infection have been published.[2][3] The causative agent, bovine viral diarrhea virus (BVDV), is a member of the genus Pestivirus of the family Flaviviridae.[1]
BVD infection results in a wide variety of clinical signs, due to its immunosuppressive effects,[4] as well as having a direct effect on respiratory disease and fertility.[5] In addition, BVD infection of a susceptible dam during a certain period of gestation can result in the production of a persistently infected (PI) fetus.[6]
PI animals recognise intra-cellular BVD viral particles as ‘self’ and shed virus in large quantities throughout life; they represent the cornerstone of the success of BVD as a disease.
Currently, it was shown in a worldwide review study that the PI prevalence at animal level ranged from low (≤0.8% Europe, North America, Australia), medium (>0.8% to 1.6% East Asia) to high (>1.6% West Asia). Countries that had failed to implement any BVDV control and/or eradication programmes (including vaccination) had the highest PI prevalence.[7]
^ abFray, M.D; Paton, D.J; Alenius, S.; et al. (2000). "The effects of bovine viral diarrhoea virus on cattle reproduction in relation to disease control". Animal Reproduction Science. 60–61: 615–27. doi:10.1016/s0378-4320(00)00082-8. PMID 10844229.
^Richter, V; Lebl, K; Baumgartner, W; Obritzhauser, W; Käsbohrer, A; Pinior, B (2017). "A systematic worldwide review of the direct monetary losses due to bovine viral diarrhea virus infection". The Veterinary Journal. 220: 80–87. doi:10.1016/j.tvjl.2017.01.005. PMID 28190502.
^Pinior, B; Firth, C; Richter, V; Lebl, K; Trauffler, M; Dzieciol, M; Hutter, S; Burgstaller, J; Obritzhauser, W; Winter, P; Käsbohrer, A (2017). "A systematic review of financial and economic assessments of bovine viral diarrhea virus (BVDV) prevention and mitigation activities worldwide". Preventive Veterinary Medicine. 137 (Pt A): 77–92. doi:10.1016/j.prevetmed.2016.12.014. PMID 28040270.
^Schaut, Robert G.; McGill, Jodi L.; Neill, John D.; Ridpath, Julia F.; Sacco, Randy E. (2015-10-02). "Bovine viral diarrhea virus type 2 in vivo infection modulates TLR4 responsiveness in differentiated myeloid cells which is associated with decreased MyD88 expression". Virus Research. 208: 44–55. doi:10.1016/j.virusres.2015.05.017. ISSN 1872-7492. PMID 26043978.
^Lanyon, Sasha R.; Hill, Fraser I.; Reichel, Michael P.; Brownlie, Joe; et al. (2014). "Bovine Viral Diarrhoea: Pathogenesis and diagnosis" (PDF). Veterinary Journal. 199 (2): 201–9. doi:10.1016/j.tvjl.2013.07.024. PMID 24053990.
^Grooms, Daniel L. (2004). "Reproductive consequences of infection with bovine viral diarrhea virus". Veterinary Clinics of North America: Food Animal Practice. 20 (1): 5–19. doi:10.1016/j.cvfa.2003.11.006. PMID 15062471.
^Scharnböck, B; Roch, Franz-Ferdinand; Richter, V; Funke, C; Firth, C; Obritzhauser, W; Baumgartner, W; Käsbohrer, A; Pinior, B (2018). "A meta-analysis of bovine viral diarrhoea virus (BVDV) prevalences in the global cattle population". Scientific Reports. 8 (1): 14420. Bibcode:2018NatSR...814420S. doi:10.1038/s41598-018-32831-2. PMC 6158279. PMID 30258185.
and 26 Related for: Bovine viral diarrhea information
Bovineviraldiarrhea (BVD), bovineviral diarrhoea (UK English) or mucosal disease, previously referred to as bovine virus diarrhea (BVD), is an economically...
Pegivirus B (GB virus D)) Genus Pestivirus (includes Pestivirus A (bovineviraldiarrhea virus 1) and Pestivirus C (classical swine fever virus, previously...
them as well. IRESs are often used by viruses as a means to ensure that viral translation is active when host translation is inhibited. These mechanisms...
RT-qPCR, RT-LAMP, and RPA for detection of Schmallenberg virus and bovineviraldiarrhea virus, which effectively makes the point that each amplification...
bacterial cause of the disease. Viral agents include Bovineviraldiarrhea (BVD), Infectious Bovine Rhinotracheitis (IBR), Bovine respiratory syncytial virus...
positive-sense RNA genomes. They cause Classical swine fever (CSF) and Bovineviraldiarrhea(BVD). Mucosal disease is a distinct, chronic persistent infection...
Peterhans E, Bachofen C, Stalder H, Schweizer M (2010). "Cytopathic bovineviraldiarrhea viruses (BVDV): emerging pestiviruses doomed to extinction". Veterinary...
as the bloody flux, is a type of gastroenteritis that results in bloody diarrhea. Other symptoms may include fever, abdominal pain, and a feeling of incomplete...
Cattle - Retinal dysplasia occurs in utero through infection with bovineviraldiarrhea. It is also inherited in Shorthorns and Herefords. Both forms often...
melioidosis symptoms during the eradication therapy. The bovineviral diarrhoea virus (bovine virus diarrhea) is said to be recrudescent for some time after clinical...
days after exposure to the virus and last for about two to eight days. Diarrhea and vomiting can occur, particularly in children. Influenza may progress...
which are the leading cause of severe diarrhea among young children. The vaccines prevent 15–34% of severe diarrhea in the developing world and 37–96% of...
Bovine malignant catarrhal fever (BMCF) is a fatal lymphoproliferative disease caused by a group of ruminant gamma herpes viruses including Alcelaphine...
X-ray crystallography in the 1970s and 80s, it was noticed that several viral proteases such as Tobacco Etch Virus protease showed structural homology...
which the GT-1b replicon system was implemented in Huh7 cells and bovineviraldiarrhea virus also in Huh7 cells was used as a counterscreen for specificity...
occurs, similar clinical signs may be caused in sheep and goats by bovineviraldiarrhea virus (BVDV). It is therefore important to identify truly infected...
Bovine coronavirus (BCV or BCoV) is a coronavirus which is a member of the species Betacoronavirus 1. The infecting virus is an enveloped, positive-sense...
lactoferrin anti-viral activity is sialic-acid–dependent. The structures of the polypeptide chain and carbohydrate moieties of bovine lactoferrin (bLF)...
Wolves may suffer from various pathogens, both viral and bacterial, and parasite, both external and internal. Parasitic infection in wolves is of particular...
lethargy, enlargement of the lymph nodes, and diarrhea. There is at least one strain that has been sequenced. Bovine immunodeficiency virus G.E., Wilcox (8 March...
include diarrhea and weight loss, and respiratory infection can produce a mucoid nasal discharge. As clinical signs are fairly nonspecific and bovine enterovirus...