In physiology and medicine, the body surface area (BSA) is the measured or calculated surface area of a human body. For many clinical purposes, BSA is a better indicator of metabolic mass than body weight because it is less affected by abnormal adipose mass. Nevertheless, there have been several important critiques of the use of BSA in determining the dosage of medications with a narrow therapeutic index, such as chemotherapy.
Typically there is a 4–10 fold variation in drug clearance between individuals due to differing the activity of drug elimination processes related to genetic and environmental factors. This can lead to significant overdosing and underdosing (and increased risk of disease recurrence). It is also thought to be a distorting factor in Phase I and II trials that may result in potentially helpful medications being prematurely rejected.[1][2] The trend to personalized medicine is one approach to counter this weakness.
^Gurney H (April 2002). "How to calculate the dose of chemotherapy". Br. J. Cancer. 86 (8): 1297–302. doi:10.1038/sj.bjc.6600139. PMC 2375356. PMID 11953888.
^Gao B, Klumpen HJ, Gurney H (October 2008). "Dose calculation of anticancer drugs". Expert Opin Drug Metab Toxicol. 4 (10): 1307–19. doi:10.1517/17425255.4.10.1307. PMID 18798700. S2CID 73327796.
The surfacearea (symbol A) of a solid object is a measure of the total area that the surface of the object occupies. The mathematical definition of surface...
absolute MET replaces the mass of a reference individual with the bodysurfacearea of a chosen reference individual. Health and fitness studies often...
index is a method of relating the stroke volume (SV) to the person's bodysurfacearea (BSA). S V I = S V B S A = ( C O / H R ) B S A = C O H R × B S A {\displaystyle...
estimate the total bodysurfacearea (BSA) affected by a burn. In addition to determining burn severity, the measurement of burn surfacearea is important for...
The accessible surfacearea (ASA) or solvent-accessible surfacearea (SASA) is the surfacearea of a biomolecule that is accessible to a solvent. Measurement...
Ringer's – is four times the product of the body weight and the burn percentage (i.e. bodysurfacearea affected by burns). The first half of the fluid...
A bodyarea network (BAN), also referred to as a wireless bodyarea network (WBAN) or a body sensor network (BSN) or a medical bodyarea network (MBAN)...
relates the cardiac output (CO) from left ventricle in one minute to bodysurfacearea (BSA), thus relating heart performance to the size of the individual...
years of age. The Surface-based Body Shape Index (SBSI) is far more rigorous and is based upon four key measurements: the bodysurfacearea (BSA), vertical...
The polar surfacearea (PSA) or topological polar surfacearea (TPSA) of a molecule is defined as the surface sum over all polar atoms or molecules, primarily...
treated with 5-FU are underdosed based on today's dosing standard, bodysurfacearea (BSA). The limitations of BSA-based dosing prevent oncologists from...
Surface anatomy (also called superficial anatomy and visual anatomy) is the study of the external features of the body of an animal. In birds, this is...
independent of the size of the subject's body, the accepted convention is to further index equation (1) using bodysurfacearea (BSA), giving rise to the Cardiac...
a tool useful in the management of burns for estimating the total bodysurfacearea affected. It was created by Dr. Charles Lund, Senior Surgeon at Boston...
with a surfacearea of more than approximately 3,000 square kilometres (1,200 sq mi), ranked by area, excluding reservoirs and lagoons. The area of some...
method of determining chemotherapy dosage is based on calculated bodysurfacearea (BSA). The BSA is usually calculated with a mathematical formula or...
that: CO = SV x HR. The cardiac output is normalized to body size through bodysurfacearea and is called the cardiac index. The average cardiac output...
minimizes surfacearea for large celestial bodies. The sphere has the smallest total mean curvature among all convex solids with a given surfacearea. The...
It is usually calculated as left atrial volume index in terms of bodysurfacearea. The left atrial volume is commonly measured by echocardiography or...
boundaries and coastlines, excluding water area. Water area: the sum of the surfaceareas of all inland water bodies (lakes, reservoirs, and rivers) within...
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