Blood smear showing red blood cells with basophilic stippling
Basophilic stippling, also known as punctate basophilia, is the presence of numerous basophilic granules that are dispersed through the cytoplasm of erythrocytes in a peripheral blood smear. They can be demonstrated to be RNA. They are composed of aggregates of ribosomes; degenerating mitochondria and siderosomes may be included in the aggregates.[citation needed] In contrast to Pappenheimer bodies, they are negative with Perls' acid ferrocyanide stain for iron (i.e. no iron in basophilic stippling).[1] Basophilic stippling is indicative of disturbed erythropoiesis. It can also be found in some normal individuals.[2]
^Le, Tao; Bhushan, Vikas; Coleman, Caroline; Jones, Stepanie; Kaparaliotis, Panagiotis; Kallianos, Kimberly, eds. (2023). First Aid for the® USMLE® Step 1 2023 (33rd ed.). New York Chicago San Francisco: McGraw Hill. p. 422. ISBN 978-1-264-94662-4.
^Cheson, B. D; Rom, W. N; Webber, R. C (1984). "Basophilic stippling of red blood cells: A nonspecific finding of multiple etiology". American Journal of Industrial Medicine. 5 (4): 327–34. doi:10.1002/ajim.4700050409. PMID 6202140.
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Basophilicstippling, also known as punctate basophilia, is the presence of numerous basophilic granules that are dispersed through the cytoplasm of erythrocytes...
bodies must be distinguished with other basophilic granules inside erythrocytes like the basophilicstippling. Contrary to the latter, they contain iron...
marrow. On the peripheral blood smear can be found erythrocytes with basophilicstippling (cytoplasmic granules of RNA precipitates) and Pappenheimer bodies...
elliptocytosis, and thalassemias demonstrate target cells and coarse basophilicstippling. In practice, though elliptocytes and anisocytosis are often seen...
(October 1976). "Lead poisoning: association with hemolytic anemia, basophilicstippling, erythrocyte pyrimidine 5'-nucleotidase deficiency, and intraerythrocytic...
of the blood lead level (BLL). Blood film examination may reveal basophilicstippling of red blood cells (dots in red blood cells visible through a microscope)...
an eosinophilic cytoplasm, reflecting numerous mitochondria, and basophilicstippling due to large amounts of rough endoplasmic reticulum and free ribosomes...
microcytic anemia, anisocytosis, poikilocytosis, chromophilic cells, and basophilicstippling on their peripheral smears. In general, aluminium concentrations...
reticulocyte and stain reddish-blue with Wright's stain. Basophilicstipplings – these stipplings are either fine or coarse, deep blue to purple staining...
by moderate hemolytic anemia, jaundice, splenomegaly, and marked basophilicstippling, and has been associated with learning difficulties. Two homozygous...
chromatin tends to spread in a semicircle or into multiple dots. There is no stippling of the erythrocyte. Mature gametocytes are larger than a normal erythrocyte...
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