A basal cell is a cell type that is present in many forms of epithelium. It is generally located between the basement membrane and the rest of the epithelium. Examples include:
The epidermal cell in the stratum basale
The airway basal cell, an epithelial cell in the respiratory epithelium
Basal cells of prostate glands
Basal cells are found in the lowest layer of the epidermis. In order to replenish the squamous cells that wear down the skin's surface, these cells divide continuously. These cells become flatter as they advance through the epidermis and give rise to squamous cells.[1] They can interact with neurons, the basement membrane, columnar epithelium, and the underlying mesenchymal cells from this pivotal position. They also engage in interactions with dendritic, lymphocyte, and inflammatory cells. The lateral intercellular gap between basal cells is where these interactions occur.[2] The most frequent types of skin cancer are basal cell and squamous cell. More than 1 million instances of non-melanoma skin cancers (NMSC) are expected to be diagnosed in the United States each year, and the incidence is rapidly increasing. Basal and squamous cell malignancies, while seldom metastatic, can cause significant local damage and disfigurement, affecting large sections of soft tissue, cartilage, and bone[3].
Prostate gland microanatomy, with basal cells found between the luminal cells and the basement membrane.
Cells of the respiratory epithelium. Basal cells shown in purple, ciliated cells shown in brown, goblet cells shown in green, and submucosal gland shown in blue.
^"Basal Cell Nevus Syndrome", Encyclopedia of Cancer, Berlin, Heidelberg: Springer Berlin Heidelberg, pp. 345–346, 2011, retrieved 2024-03-27
^"What Are Basal and Squamous Cell Skin Cancers? | Types of Skin Cancer". www.cancer.org. Retrieved 2024-03-27.
^Miller, Stanley J.; Alam, Murad; Andersen, James; et al. (August 2010). "Basal Cell and Squamous Cell Skin Cancers". Journal of the National Comprehensive Cancer Network. 8 (8): 836–864. doi:10.6004/jnccn.2010.0062. ISSN 1540-1405.
epidermal cell in the stratum basale The airway basalcell, an epithelial cell in the respiratory epithelium Basalcells of prostate glands Basalcells are...
of the cell. Some basalcells can act like stem cells with the ability to divide and produce new cells, and these are sometimes called basal keratinocyte...
Airway basalcells are found deep in the respiratory epithelium, attached to, and lining the basement membrane. Basalcells are the stem cells or progenitors...
associated with other skin conditions, including basalcell carcinoma. Rarely, seborrheic keratosis and basalcell carcinoma occur at the same location. At clinical...
nonmelanoma skin cancers, about 80% are basal-cell cancers and 20% squamous-cell skin cancers. Basal-cell and squamous-cell skin cancers rarely result in death...
epithelium.: 3 The basal lamina is made up of laminin (glycoproteins) secreted by epithelial cells. The reticular lamina beneath the basal lamina is made...
(squamous) cells. The basal membrane provides the support for the first layer of the epithelium-the basal layer. The intermediate layers lie upon the basal layer...
Basalcell adenoma is a rare, low-grade benign salivary gland neoplasm. The most common involved site is the parotid gland, however other possible sites...
are squamous cell cancers. Other types include adenocarcinoma, melanoma, sarcoma, and basalcell carcinoma. Diagnosis is suspected based on physical examination...
and 99.8% for primary basal-cell carcinoma, the most common type of skin cancer.: 13 Mohs procedure is also used for squamous cell carcinoma, but with...
Basalcell adhesion molecule, also known as Lutheran antigen, is a plasma membrane glycoprotein that in humans is encoded by the BCAM gene. BCAM has also...
clearance works. The basalcells are small, nearly cuboidal that differentiate into the other cell types found within the epithelium. Basalcells respond to injury...
basal cell population that expresses the c-KIT cell surface protein. Resting on or near the basal lamina of the olfactory epithelium, basalcells are stem...
two weeks are needed for a cell to migrate from the basalcell layer to the top of the granular cell layer, and an additional two weeks to cross the stratum...
with columnar cells in the basal layer which have focal reverse polarisation (nuclei are on the opposite pole of the cell). The basalcells are an indication...
the basal body in such a cell is derived from the centriole. The basal body differs from the mother centriole in at least 2 aspects. First, basal bodies...
Cohen PR (March 2017). "Red Dot BasalCell Carcinoma: Report of Cases and Review of This Unique Presentation of BasalCell Carcinoma". Cureus. 9 (3): e1110...
surgeons and general practitioners for the treatment of basalcell cancers and squamous cell cancers of the skin. It provides desiccation, coagulation/cauterization...
The basal ganglia (BG) or basal nuclei are a group of subcortical nuclei found in the brains of vertebrates. In humans and other primates, differences...
mainly used to aid in the diagnosis of basalcell carcinoma (BCC). It is an antibody to EpCAM (epithelial cell adhesion molecule). BerEp4 has a high sensitivity...
(May-Grünwald Giemsa x1000). A cluster of basaloid cells on a smear taken from a patient with basalcell carcinoma (May-Grünwald Giemsa x1000). Durdu M (2019)...
Global Information
Prostate gland microanatomy, with basal cells found between the luminal cells and the basement membrane.
Cells of the respiratory epithelium. Basal cells shown in purple, ciliated cells shown in brown, goblet cells shown in green, and submucosal gland shown in blue.
