Balkan endemic nephropathy[1] (BEN) is a form of interstitial nephritis causing kidney failure. It was first identified in the 1920s among several small, discrete communities along the Danube River and its major tributaries, in the modern countries of Croatia, Bosnia and Herzegovina, Serbia, Kosovo, Romania, and Bulgaria. It is caused by small long-term doses of aristolochic acid in the diet. The disease primarily affects people 30 to 60 years of age. Doses of the toxin are usually low and people moving to endemic areas typically develop the condition only when they have lived there for 10–20 years. People taking higher doses of aristolochic acid (as Chinese herbal supplements) have developed kidney failure after shorter durations of exposure.[2]
^Online Mendelian Inheritance in Man (OMIM): 124100
^Stiborová, M., Arlt, V.M. & Schmeiser, H.H. Balkan endemic nephropathy: an update on its aetiology. Arch Toxicol 90, 2595–2615 (2016). https://doi.org/10.1007/s00204-016-1819-3
and 13 Related for: Balkan endemic nephropathy information
Balkanendemicnephropathy (BEN) is a form of interstitial nephritis causing kidney failure. It was first identified in the 1920s among several small,...
transitional cell (urothelial) urinary cancers seems abnormally high in Balkanendemicnephropathy patients, especially for the upper urinary tract. The molecular...
disease. The Balkanendemicnephropathy was found to be caused by chronic intake of aristolochic acid, while the causes of Mesoamerican nephropathy that occurs...
“Chinese herbs nephropathy” (CHN) due to the origin of the weight-loss supplement. A similar condition previously known as Balkanendemicnephropathy (BEN), first...
mammalian kidneys. Exposure to ochratoxin A has been associated with Balkanendemicnephropathy, a kidney disease with high mortality in people living near tributaries...
D. (2012). "Chinese herbs nephropathy and Balkanendemicnephropathy: Toward a single entity, aristolochic acid nephropathy". Kidney International. 81...
(November 1991). "Renal function, protein excretion, and pathology of Balkanendemicnephropathy. IV. Immunohistology". Kidney International. 34: S68-74. PMID 1762338...
(January 2010). "Mycotoxic nephropathy in Bulgarian pigs and chickens: complex aetiology and similarity to Balkanendemicnephropathy" (PDF). Food Additives...
involved in the pathogenesis of a human kidney disease, called BalkanEndemicNephropathy. The interaction of both substances might also influence apoptosis...
Bojan (17 July 2007). "Aristolochic acid and the etiology of endemic (Balkan) nephropathy". Proceedings of the National Academy of Sciences of the United...
Bulgaria, Yugoslavia and Romania. This occurrence was called the BalkanEndemicNephropathy that was being caused by the consumption of contaminated pig meat...
kidneys and is thought to be one of the culprits involved in the Balkanendemicnephropathy. Despite the lack of regulations, there have been various studies...
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