Cellular object readily stainable with a RomanowskI stain
Azurophilic granule
Details
Identifiers
Latin
Granulum azurophilum
TH
H2.00.04.1.02011, H2.00.04.1.02014
Anatomical terms of microanatomy
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An azurophilic granule is a cellular object readily stainable with a Romanowsky stain. In white blood cells and hyperchromatin, staining imparts a burgundy or merlot coloration. Neutrophils in particular are known for containing azurophils loaded with a wide variety of anti-microbial defensins that fuse with phagocytic vacuoles. Azurophils may contain myeloperoxidase, phospholipase A2, acid hydrolases, elastase, defensins, neutral serine proteases, bactericidal permeability-increasing protein,[1] lysozyme, cathepsin G, proteinase 3, and proteoglycans.[citation needed]
Azurophil granules are also known as "primary granules".[2]
Furthermore, the term "azurophils" may refer to a unique type of cells, identified only in reptiles. These cells are similar in size to so-called heterophils with abundant cytoplasm that is finely to coarsely granular and may sometimes contain vacuoles. Granules may impart a purplish hue to the cytoplasm, particularly to the outer region. Occasionally, azurophils are observed with vacuolated cytoplasm.[3]
^"Phagocytes-Neutrophils". Archived from the original on 2008-08-21.
^John P. Greer; Maxwell Myer Wintrobe (1 December 2008). Wintrobe's clinical hematology. Lippincott Williams & Wilkins. p. 173. ISBN 978-0-7817-6507-7. Retrieved 10 November 2010.
^Bonnie Ballard; Ryan Cheek (May 4, 2010). Exotic Animal Medicine for the Veterinary Technician (2 ed.). Wiley-Blackwell. p. 391. ISBN 978-0813822068.
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An azurophilicgranule is a cellular object readily stainable with a Romanowsky stain. In white blood cells and hyperchromatin, staining imparts a burgundy...
features of unknown function Azurophilicgranule, a structure characteristic of the azurophil eukaryotic cell type Chromaffin granule, a structure characteristic...
Neutrophils have two types of granules; primary (azurophilic) granules (found in young cells) and secondary (specific) granules (which are found in more mature...
proteins from azurophilicgranules (neutrophil elastase, cathepsin G and myeloperoxidase), specific granules (lactoferrin), tertiary granules (gelatinase)...
is absent.: 170 The cytoplasm also contains about 200 granules, of which a third are azurophilic.: 170 Neutrophils will show increasing segmentation (many...
which is the chemical in bleach. It is a lysosomal protein stored in azurophilicgranules of the neutrophil and released into the extracellular space during...
APL, as hypergranual promyelocytes are characterized by the dense azurophilicgranule concentrations in the cytoplasm. APL is often associated with a specific...
cytoplasm is gray, pale blue, or deep blue in color; vacuoles and/or azurophilicgranules are also sometimes present; histochemistry shows increased concentrations...
expressed in monocytes and granulocytes and is a potent inhibitor of the azurophilicgranule protease, cathepsin G". Blood. 93 (6): 2089–2097. doi:10.1182/blood...
endoreduplication and forms a promegakaryocyte which has multiple nuclei, azurophilicgranules, and a basophilic cytoplasm. The promegakaryocyte has rotary motion...
neoplastic lymphocytes seen in this disease are large in size with azurophilicgranules that contains proteins involved in cell lysis such as perforin and...
stains moderately to lightly basophilic and may contain small azurophilicgranules. These granules contain enzymes that can damage or digest pathogens and also...
white blood cells detects leukocyte esterase, which is present in azurophilicgranules of monocytes and granulocytes (neutrophilic, eosinophilic and basophilic)...
lysosomal enzymes, Auer rods are azurophilic and can resemble needles, commas, diamonds, rectangles, corkscrews, or (rarely) granules. Although Auer rods are named...
development. Recently, granule-specific glycosylation was shown in neutrophils featuring prominent paucimannosylation in the azurophilicgranules an observation...
peroxidase reaction. Eosinophil peroxidase can be found in the primary (azurophilic) granules of human and mammalian leukocytes. Peroxidase localization in leukocytes...
process is unaffected. The underlying reason is the impairment of azurophilicgranules, the lysosome-related organelles responsible for the lysis of bacteria...
v t e Contents of the granules of granulocytes Azurophilicgranules (1°) Myeloperoxidase Defensins neutral serine proteases (Proteinase 3) Lysozyme Bactericidal...
example, tissues that stain with an azure stain may be referred to as azurophilic. This may also be used for more generalized staining properties, such...
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