Global Information Lookup Global Information

Azurophilic granule information


Azurophilic granule
Details
Identifiers
LatinGranulum azurophilum
THH2.00.04.1.02011, H2.00.04.1.02014
Anatomical terms of microanatomy
[edit on Wikidata]

An azurophilic granule is a cellular object readily stainable with a Romanowsky stain. In white blood cells and hyperchromatin, staining imparts a burgundy or merlot coloration. Neutrophils in particular are known for containing azurophils loaded with a wide variety of anti-microbial defensins that fuse with phagocytic vacuoles. Azurophils may contain myeloperoxidase, phospholipase A2, acid hydrolases, elastase, defensins, neutral serine proteases, bactericidal permeability-increasing protein,[1] lysozyme, cathepsin G, proteinase 3, and proteoglycans.[citation needed]

Azurophil granules are also known as "primary granules".[2]

Furthermore, the term "azurophils" may refer to a unique type of cells, identified only in reptiles. These cells are similar in size to so-called heterophils with abundant cytoplasm that is finely to coarsely granular and may sometimes contain vacuoles. Granules may impart a purplish hue to the cytoplasm, particularly to the outer region. Occasionally, azurophils are observed with vacuolated cytoplasm.[3]

  1. ^ "Phagocytes-Neutrophils". Archived from the original on 2008-08-21.
  2. ^ John P. Greer; Maxwell Myer Wintrobe (1 December 2008). Wintrobe's clinical hematology. Lippincott Williams & Wilkins. p. 173. ISBN 978-0-7817-6507-7. Retrieved 10 November 2010.
  3. ^ Bonnie Ballard; Ryan Cheek (May 4, 2010). Exotic Animal Medicine for the Veterinary Technician (2 ed.). Wiley-Blackwell. p. 391. ISBN 978-0813822068.

and 21 Related for: Azurophilic granule information

Request time (Page generated in 0.8925 seconds.)

Azurophilic granule

Last Update:

An azurophilic granule is a cellular object readily stainable with a Romanowsky stain. In white blood cells and hyperchromatin, staining imparts a burgundy...

Word Count : 216

Granule

Last Update:

features of unknown function Azurophilic granule, a structure characteristic of the azurophil eukaryotic cell type Chromaffin granule, a structure characteristic...

Word Count : 225

Granulocyte

Last Update:

Neutrophils have two types of granules; primary (azurophilic) granules (found in young cells) and secondary (specific) granules (which are found in more mature...

Word Count : 2352

Neutrophil extracellular traps

Last Update:

proteins from azurophilic granules (neutrophil elastase, cathepsin G and myeloperoxidase), specific granules (lactoferrin), tertiary granules (gelatinase)...

Word Count : 3020

Neutrophil

Last Update:

is absent.: 170  The cytoplasm also contains about 200 granules, of which a third are azurophilic.: 170  Neutrophils will show increasing segmentation (many...

Word Count : 5605

Myeloperoxidase

Last Update:

which is the chemical in bleach. It is a lysosomal protein stored in azurophilic granules of the neutrophil and released into the extracellular space during...

Word Count : 1879

Promyelocyte

Last Update:

APL, as hypergranual promyelocytes are characterized by the dense azurophilic granule concentrations in the cytoplasm. APL is often associated with a specific...

Word Count : 1079

Reactive lymphocyte

Last Update:

cytoplasm is gray, pale blue, or deep blue in color; vacuoles and/or azurophilic granules are also sometimes present; histochemistry shows increased concentrations...

Word Count : 1127

Serpin

Last Update:

expressed in monocytes and granulocytes and is a potent inhibitor of the azurophilic granule protease, cathepsin G". Blood. 93 (6): 2089–2097. doi:10.1182/blood...

Word Count : 14251

Myelodysplastic syndrome

Last Update:

Pelger-Huet) Hypogranular neutrophils or pseudo Chediak-Higashi (large azurophilic granules) Auer rods – automatically RAEB II (if blast count < 5% in the peripheral...

Word Count : 6312

Large granular lymphocytic leukemia

Last Update:

neoplastic lymphocytes seen in this disease are large in size with azurophilic granules that contains proteins involved in cell lysis such as perforin and...

Word Count : 1539

Promegakaryocyte

Last Update:

endoreduplication and forms a promegakaryocyte which has multiple nuclei, azurophilic granules, and a basophilic cytoplasm. The promegakaryocyte has rotary motion...

Word Count : 416

Auer rod

Last Update:

lysosomal enzymes, Auer rods are azurophilic and can resemble needles, commas, diamonds, rectangles, corkscrews, or (rarely) granules. Although Auer rods are named...

Word Count : 252

Urine test strip

Last Update:

white blood cells detects leukocyte esterase, which is present in azurophilic granules of monocytes and granulocytes (neutrophilic, eosinophilic and basophilic)...

Word Count : 6376

Monoblast

Last Update:

stains moderately to lightly basophilic and may contain small azurophilic granules. These granules contain enzymes that can damage or digest pathogens and also...

Word Count : 806

P14 deficiency

Last Update:

process is unaffected. The underlying reason is the impairment of azurophilic granules, the lysosome-related organelles responsible for the lysis of bacteria...

Word Count : 2487

Paucimannosylation

Last Update:

development. Recently, granule-specific glycosylation was shown in neutrophils featuring prominent paucimannosylation in the azurophilic granules an observation...

Word Count : 6223

Eosinophil peroxidase

Last Update:

peroxidase reaction. Eosinophil peroxidase can be found in the primary (azurophilic) granules of human and mammalian leukocytes. Peroxidase localization in leukocytes...

Word Count : 2880

Outline of immunology

Last Update:

v t e Contents of the granules of granulocytes Azurophilic granules (1°) Myeloperoxidase Defensins neutral serine proteases (Proteinase 3) Lysozyme Bactericidal...

Word Count : 2656

Inflammation

Last Update:

ingesting bacteria, viruses, and cellular debris. Others release enzymatic granules that damage pathogenic invaders. Leukocytes also release inflammatory mediators...

Word Count : 9469

Staining

Last Update:

example, tissues that stain with an azure stain may be referred to as azurophilic. This may also be used for more generalized staining properties, such...

Word Count : 5308

PDF Search Engine © AllGlobal.net