Auranofin information

Auranofin
Clinical data
Trade names	Ridaura
AHFS/Drugs.com	Consumer Drug Information
MedlinePlus	a685038
Pregnancy; category	AU: B3; ;
Routes of; administration	Oral
ATC code	M01CB03 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); UK: POM (Prescription only); US: WARNINGRx-only;
Pharmacokinetic data
Bioavailability	40%
Protein binding	60%
Metabolism	Plasma membrane of the cell removes the acetyl groups of the glucose moiety.
Elimination half-life	21-31 days
Excretion	Urine (60%), faeces
Identifiers
	IUPAC name Gold(+1) cation; 3,4,5-triacetyloxy-6- (acetyloxymethyl) oxane-2-thiolate; triethylphosphanium;
CAS Number	34031-32-8 ;
PubChem CID	6333901;
DrugBank	DB00995 ;
ChemSpider	21242895 ;
UNII	3H04W2810V;
KEGG	D00237 ;
ChEBI	CHEBI:2922 ;
ChEMBL	ChEMBL1366 ;
CompTox Dashboard (EPA)	DTXSID4020115 ;
ECHA InfoCard	100.047.077
Chemical and physical data
Formula	C20H34AuO9PS0
Molar mass	678.48 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCP(=[Au]S[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)COC(=O)C)OC(=O)C)OC(=O)C)OC(=O)C)(CC)CC;
	InChI InChI=1S/C14H20O9S.C6H15P.Au/c1-6(15)19-5-10-11(20-7(2)16)12(21-8(3)17)13(14(24)23-10)22-9(4)18;1-4-7(5-2)6-3;/h10-14,24H,5H2,1-4H3;4-6H2,1-3H3;/q;;+1/p-1/t10-,11-,12+,13-,14+;;/m1../s1 ; Key:AUJRCFUBUPVWSZ-XTZHGVARSA-M ;
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Auranofin is a gold salt classified by the World Health Organization as an antirheumatic agent. It has the brand name Ridaura.

^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
^ ^a ^b ^c ^d Kean WF, Hart L, Buchanan WW (May 1997). "Auranofin". British Journal of Rheumatology. 36 (5): 560–572. doi:10.1093/rheumatology/36.5.560. PMID 9189058.
^ ^a ^b ^c ^d "Ridaura (auranofin) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Retrieved 13 March 2014.

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