This article is about sequestering agents in general. For chemicals used in food processing, see Sequestrant.
Chelation is a type of bonding of ions and the molecules to metal ions. It involves the formation or presence of two or more separate coordinate bonds between a polydentate (multiple bonded) ligand and a single central metal atom.[1][2] These ligands are called chelants, chelators, chelating agents, or sequestering agents. They are usually organic compounds, but this is not a necessity.
The word chelation is derived from Greek χηλή, chēlē, meaning "claw"; the ligands lie around the central atom like the claws of a crab. The term chelate was first applied in 1920 by Sir Gilbert T. Morgan and H. D. K. Drew, who stated: "The adjective chelate, derived from the great claw or chele (Greek) of the crab or other crustaceans, is suggested for the caliperlike groups which function as two associating units and fasten to the central atom so as to produce heterocyclic rings."[3]
Chelation is useful in applications such as providing nutritional supplements, in chelation therapy to remove toxic metals from the body, as contrast agents in MRI scanning, in manufacturing using homogeneous catalysts, in chemical water treatment to assist in the removal of metals, and in fertilizers.
^IUPAC definition of chelation.
^Latin chela, from Greek, denotes a claw.
^Morgan GT, Drew HD (1920). "CLXII.—Researches on residual affinity and co-ordination. Part II. Acetylacetones of selenium and tellurium". Journal of the Chemical Society, Transactions. 117: 1456–65. doi:10.1039/ct9201701456.
Chelation is a type of bonding of ions and the molecules to metal ions. It involves the formation or presence of two or more separate coordinate bonds...
Chelation therapy is a medical procedure that involves the administration of chelating agents to remove heavy metals from the body. Chelation therapy...
edetate, an EDTA derivative, is used to bind metal ions in the practice of chelation therapy, such as for treating mercury and lead poisoning. It is used in...
mercury. In those with acute poisoning from inorganic mercury salts, chelation with either dimercaptosuccinic acid (DMSA) or dimercaptopropane sulfonate...
that bind lead so it can be eliminated from the body, known as chelation therapy. Chelation therapy in children is recommended when blood levels are greater...
Sodium calcium edetate (sodium calcium EDTA), also known as edetate calcium disodium among other names, is a medication primarily used to treat lead poisoning...
promoted the disproven idea that vaccines cause autism, and said that chelation therapy, a quack remedy, helped cure her son of autism. McCarthy's proselytization...
and tetracycline antibiotics, iron, itraconazole, and prednisone. Metal chelation is responsible for some of these interactions (e.g. fluoroquinolones,...
disease often includes regular blood transfusions, iron chelation, and folic acid. Iron chelation may be done with deferoxamine, deferasirox or deferiprone...
licensed osteopathic physician. He was known for his controversial use of chelation therapy for numerous conditions, including autism and cancer. He was twice...
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poisoning from potassium gold cyanide. Gold toxicity can be ameliorated with chelation therapy with an agent such as dimercaprol. Gold metal was voted Allergen...
iron chelation therapy, the iron loading rates vary. Monitoring of transfusion iron overload is essential for effective and safe iron chelation tailored...
physician Julius Stumpf. It has been used as a scientifically unsupported chelation treatment for heart disease and autism. Bentonite has the ability to reduce...
for treatment of metal poisoning may be chelation therapy, a technique involving the administration of chelation agents to remove metals from the body....
treatment of autism, including vaccine denial, facilitated communication, chelation therapy, and false claims of a link between secretin and autism. He also...
metal chelation, it has been used to immobilize Deferoxamine to surfaces and substrates for various industrial and biomedical applications. Chelation therapy...
molecule may also bind to other receptors than those said to be "selective". Chelation therapy is a form of medical treatment in which a chelating ligand is...
American Academy of Clinical Toxicology recommend against chelation therapy and say that chelation therapy can artificially and temporarily elevate the levels...
through eluviation and then depositing. Metal ions that can participate in chelation include Fe, Al, Mn, Ca, Mg and trace elements in soil, while the organic...
biomolecular targets: targeted therapy molecular chaperone therapy by chelation: chelation therapy by specific chemical elements: by metals: by heavy metals:...
side effects in sub-chronic studies. Interestingly, the simultaneous chelation of Fe2+ and Fe3+ increases the treatment efficacy. Persons with symptomatic...
by techniques such as dialysis and (in a very limited number of cases) chelation therapy. There is a firm scientific base in evidence-based medicine for...
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