Structure of ascorbate peroxidase in complex with ascorbate (in blue); a histidine ligand (in red) coordinates to the iron of the heme group (also in red). Image taken from PDB 1OAF and created using Pymol
Identifiers
EC no.
1.11.1.11
CAS no.
72906-87-7
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BRENDA
BRENDA entry
ExPASy
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KEGG
KEGG entry
MetaCyc
metabolic pathway
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Ascorbate peroxidase (or L-ascorbate peroxidase, APX or APEX) (EC 1.11.1.11) is an enzyme that catalyzes the chemical reaction
L-ascorbate + H2O2 dehydroascorbate + 2 H2O
It is a member of the family of heme-containing peroxidases. Heme peroxidases catalyse the H2O2-dependent oxidation of a wide range of different, usually organic, substrates in biology.
This enzyme belongs to the family of oxidoreductases, specifically those acting on a peroxide as acceptor (peroxidases). The systematic name of this enzyme class is L-ascorbate:hydrogen-peroxide oxidoreductase. Other names in common use include L-ascorbic acid peroxidase, L-ascorbic acid-specific peroxidase, ascorbate peroxidase, and ascorbic acid peroxidase. This enzyme participates in ascorbate and aldarate metabolism.
and 24 Related for: Ascorbate peroxidase information
Ascorbateperoxidase (or L-ascorbateperoxidase, APX or APEX) (EC 1.11.1.11) is an enzyme that catalyzes the chemical reaction L-ascorbate + H2O2 ⇌ {\displaystyle...
Cytochrome c peroxidase is used as a soluble, easily purified model for cytochrome c oxidase. Biology portal Ascorbateperoxidase Chloride peroxidase Cytochrome...
metabolites and enzyme systems, such as ascorbate in the glutathione-ascorbate cycle, glutathione peroxidases and glutaredoxins, as well as reacting directly...
couple hours. CCP has high sequence identity to the closely related ascorbateperoxidase enzyme. Amino acid analyzer studies reveal presence of residues of...
pathway. Both taxifolin and coniferyl alcohol will be oxidized by ascorbateperoxidase 1 to enable the single electron reaction to couple two fragments...
the tongue Acetone peroxide, a highly explosive organic peroxide Ascorbateperoxidase, an enzyme that catalyses the reaction between biotin-phenol and...
instead of the ~18 hour labeling times required by BioID. APEX is an ascorbateperoxidase derivative reliant on hydrogen peroxide for catalyzing the oxidation...
oxygen species scavenging enzymes such as superoxide dismutase and ascorbateperoxidase, which protect the photobiont from oxidative damage during dehydration...
labeling approaches. One of these proximity labeling approaches is the ascorbateperoxidase (APEX) method, in which cells are engineered to express a known stress...
photochemical H 2O 2 is then reduced by the action of ascorbateperoxidase to form water and oxidized ascorbate. Asada argued that oxygen presents an important...
2002). "Substrate Binding and Catalytic Mechanism in AscorbatePeroxidase: Evidence for Two Ascorbate Binding Sites †". Biochemistry. 41 (46): 13774–13781...
Dolai, Subhankar; Yadav, Rajesh K.; Adak, Subrata (23 June 2010). "AscorbatePeroxidase from Leishmania major Controls the Virulence of Infective Stage of...
and hydrogen peroxide-scavenging enzymes (catalase, ascorbateperoxidase, and glutathione peroxidase). The antioxidant superoxide dismutase catalyses the...
Dietz KJ (January 2016). "Thiol-Based Peroxidases and AscorbatePeroxidases: Why Plants Rely on Multiple Peroxidase Systems in the Photosynthesizing Chloroplast...
which is a signal to downregulate its own expression of ascorbate oxidase and ascorbateperoxidase. AO and AP are reactive oxygen species scavengers, and...
is involved in stress management. It is a component of the glutathione-ascorbate cycle, a system that reduces poisonous hydrogen peroxide. It is the precursor...
including: catalase, superoxide dismutase, glutathione reductase, and ascorbateperoxidase (to scavenge hydrogen peroxide). After conducting his research on...
Miyachi, S.; Miyake, C.; Yokota, A. (2001). "Characterization of ascorbateperoxidases from unicellular red alga Galdieria partita". Plant & Cell Physiology...
glutathione reductase, which converts reactive H2O2 into H2O by glutathione peroxidase. If absent, the H2O2 would be converted to hydroxyl free radicals by Fenton...
bicarbonate and antioxidants such as vitamin E and vitamin C. In mild cases, ascorbate and N-acetylcysteine have been shown to increase glutathione levels and...
in the specimen container. Vegetable peroxidase and bacterial enzymes, including an Escherichia coli peroxidase, may also cause false-positive reactions...
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