Aromatic compounds containing Halogen atom(s) in place of Hydrogen
In organic chemistry, an aryl halide (also known as haloarene) is an aromatic compound in which one or more hydrogen atoms, directly bonded to an aromatic ring are replaced by a halide. The haloarene are different from haloalkanes because they exhibit many differences in methods of preparation and properties. The most important members are the aryl chlorides, but the class of compounds is so broad that there are many derivatives and applications.
In organic chemistry, an arylhalide (also known as haloarene) is an aromatic compound in which one or more hydrogen atoms, directly bonded to an aromatic...
well for arylhalides (e.g. bromobenzene, see Ullmann condensation below). Likewise, this method only gives the best yields for primary halides. Secondary...
form a carbon–carbon bond between a terminal alkyne and an aryl or vinyl halide. R1: aryl or vinyl R2: arbitrary X: I, Br, Cl or OTf The Sonogashira cross-coupling...
phthalimide. Arylhalides are much less reactive toward amines and for that reason are more controllable. A popular way to prepare aryl amines is the...
reagent would attack the ester group over the arylhalide. For the coupling of arylhalides with aryl Grignard reagents, nickel chloride in tetrahydrofuran...
a comparatively easy method to make arylhalides as the gaseous product can be separated easily from arylhalide. When an iodide is to be made, copper...
reagents can be used for the Suzuki coupling, e.g., aryl or vinyl boronic acids and aryl or vinyl halides. Work has also extended the scope of the reaction...
The Sandmeyer reaction is a chemical reaction used to synthesize arylhalides from aryl diazonium salts using copper salts as reagents or catalysts. It...
reaction is the copper-promoted conversion of arylhalides to aryl ethers, aryl thioethers, aryl nitriles, and aryl amines. These reactions are examples of...
reaction that replaces an alkyl or arylhalide with a formyl group using a N,N-disubstituted formamide. For primary alkyl halides this produces the homologous...
retention of subtrate’s configuration. Organocopper compounds couple with arylhalides (see Ullmann condensation and Ullmann reaction): ArX + ( Ar ′ ) 2 CuLi...
be any organic group, such as an alkyl or an aryl, and X is an inorganic or organic anion, such as a halide. According to X-ray crystallography the C−N+≡N...
involving aryl chlorides and aryl tosylates. Both palladium and copper complexes of the compound exhibit high activity for the coupling of arylhalides and...
introduced. The classical Ullmann reaction is limited to electron deficient arylhalides (hence the example of 2-nitrophenyl chloride above) and requires harsh...
2-dichloroethane. Traditionally, aryl amination is difficult reaction which usually requires "activated" arylhalides, such as those with strong electron-withdrawing...
carbonate, and sodium acetate. The aryl electrophile can be a halide (Br, Cl) or a triflate as well as benzyl or vinyl halides. The alkene must contain at least...
to slow reactions. The organic residue R = alkenyl, aryl, allyl, alkynyl or propargyl. The halide X' in the organozinc compound can be chloride, bromine...
neopentyl) halides, and exceptionally well for allyl, benzyl, and α-carbonyl halides. Secondary halides are far less reactive. Vinyl, aryl and tertiary...
solvent. Aryl methane-sulfonates are deprotected and then followed by a nucleophilic aromatic substitution (SNAr) with activated arylhalides. As a base...
can displace halide substituents on a carbon atom through the SN2 mechanism. With a catalyst, they also alkylate alkyl and arylhalides, as exemplified...
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