The structure of Arsphenamine has been proposed to be akin to the dimer azobenzene (A), but mass spectral studies published in 2005 suggest[1] it is actually a mixture of the trimer (B) and the pentamer (C).
Arsphenamine, also known as Salvarsan or compound 606, is an antibiotic drug that was introduced at the beginning of the 1910s as the first effective treatment for syphilis, relapsing fever, and African trypanosomiasis.[2][3]
This organoarsenic compound was the first modern antimicrobial agent.[4]
^Cite error: The named reference pmid15624113 was invoked but never defined (see the help page).
^Gibaud, Stéphane; Jaouen, Gérard (2010). "Arsenic-Based Drugs: From Fowler's Solution to Modern Anticancer Chemotherapy". Medicinal Organometallic Chemistry. Topics in Organometallic Chemistry. Vol. 32. pp. 1–20. Bibcode:2010moc..book....1G. doi:10.1007/978-3-642-13185-1_1. ISBN 978-3-642-13184-4.
^Ehrlich1 Hata2, Paul1 Sahachiro2 (1911). The Experimental Chemotherapy of Spirilloses. Rebman.{{cite book}}: CS1 maint: numeric names: authors list (link)
^Cite error: The named reference Williams was invoked but never defined (see the help page).
Arsphenamine, also known as Salvarsan or compound 606, is an antibiotic drug that was introduced at the beginning of the 1910s as the first effective treatment...
synthetic antibacterial organoarsenic compound salvarsan, now called arsphenamine. This heralded the era of antibacterial treatment that was begun with...
bubonic plague under Kitasato Shibasaburō and assisted in developing the Arsphenamine drug in 1909 in the laboratory of Paul Ehrlich. Hata received three unsuccessful...
ability to diagnose numerous blood diseases. His laboratory discovered arsphenamine (Salvarsan), the first antibiotic and first effective medicinal treatment...
discovered by Edward Jenner and Louis Pasteur. The first antibiotic was arsphenamine (Salvarsan) discovered by Paul Ehrlich in 1908 after he observed that...
active than the parent compound. The first synthetic antimicrobial drug, arsphenamine, discovered in 1909 by Sahachiro Hata in the laboratory of Paul Ehrlich...
a timeline of the development of the antibiotics themselves. 1911 – Arsphenamine, also Salvarsan 1912 – Neosalvarsan 1935 – Prontosil (an oral precursor...
in the first year of life exceeded 10%.[failed verification] In 1911 arsphenamine, the first synthetic anti-infective drug, was developed by Paul Ehrlich...
reaction is a qualitative reaction for demonstrating the presence of arsphenamine and neoarsphenamine in blood and urine. It is named for Isaak Abelin...
in the 1940s, patients were treated with arsenic-based drugs such as Arsphenamine which took a year or more to clear the infection. Beginning in the 1980s...
Joseph Igersheimer (1879–1965), best known for his discoveries with arsphenamine for the treatment of syphilis. He fled to Turkey in 1933. As one of eight...
Paul Ehrlich and his laboratory group began developing arsenic-based arsphenamine, (Salvarsan), as the first effective medicinal treatment of syphilis...
synthesized the first hormone, Adrenaline. In 1907 Alfred Bertheim synthesized Arsphenamine, the first man-made antibiotic. In 1927 Erik Rotheim patented the first...
were used as medicines, including arsphenamine (by Paul Ehrlich) and arsenic trioxide (by Thomas Fowler). Arsphenamine, as well as neosalvarsan, was indicated...
Igersheimer(1879–1965) was a German born ophthalmologist known for his work on arsphenamine for the treatment of syphilis. A Jew, after escaping the Nazis, While...
Williams, KJ (2009-08-01). "The introduction of 'chemotherapy' using arsphenamine – the first magic bullet". Journal of the Royal Society of Medicine....
the treatment of cancer. The first modern chemotherapeutic agent was arsphenamine, an arsenic compound discovered in 1907 and used to treat syphilis. This...
the early twentieth century, when Sahachiro Hata injected them with arsphenamine, which became known as "the magic bullet" for treating syphilis. They...
syphilis. Ehrlich then found that arsphenamine was found effective against syphilis spirochetes. The arsphenamines was then made available in 1910, known...
Erich Hoffmann, in 1905. The first effective treatment for syphilis was arsphenamine, discovered by Sahachiro Hata in 1909, during a survey of hundreds of...
Ehrlich and Bertheim's 606th arsenobenzene, synthesized in 1907, was arsphenamine, found ineffective against trypanosomes, but found in 1909 by Ehrlich...
1906: Walther Nernst: Third law of thermodynamics 1907: Alfred Bertheim: Arsphenamine, the first modern chemotherapeutic agent 1909: Fritz Haber: Haber Process...
severe. At that time, treatment included arsenic-based compounds such as arsphenamine (branded as the "606" formula). Initially, subjects were studied for...
such major figures as Ehrlich, who discovered the first antibiotic, arsphenamine and Gerhard Domagk, who created the first commercially available antibiotic...
disease (Aphthovirus) by Friedrich Loeffler 1907–1910: First synthesis of arsphenamine, the first antibiotic, by Paul Ehrlich and Alfred Bertheim. In 1910 marketed...
they called "bad blood" was actually syphilis. When the study started, arsphenamine (Salvarsan) and Neosalvarsan were the only available treatments for syphilis...
have syphilis. In 1936, a public health campaign began to prescribe arsphenamine to treat syphilis. Between 1945 and 1955 penicillin was used to treat...
worth pursuing with more research: 88–91 —and that early wins such as arsphenamine were more than just isolated flukes. This was a time period when organic...
Global Information