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Androgen suppression information


Androgen suppression
Other namesTestosterone suppression; Androgen ablation; Androgen deprivation
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Androgen suppression, also known as testosterone suppression, is a medical treatment to suppress or block the production or action of male sex hormones, typically in order to attempt to treat certain types of cancer that rely upon male hormones for its growth.

This is done by having the testicles removed, by taking female sex hormones, or by taking drugs called antiandrogens.

Androgen suppression is employed in androgen deprivation therapy for prostate cancer and in feminizing hormone therapy in transgender women, among other androgen-dependent indications.

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Androgen suppression

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Androgen suppression, also known as testosterone suppression, is a medical treatment to suppress or block the production or action of male sex hormones...

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Androgen deprivation therapy

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Androgen deprivation therapy (ADT), also called androgen ablation therapy or androgen suppression therapy, is an antihormone therapy whose main use is...

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Antiandrogen

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Antiandrogens, also known as androgen antagonists or testosterone blockers, are a class of drugs that prevent androgens like testosterone and dihydrotestosterone...

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Selective androgen receptor modulator

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Selective androgen receptor modulators (SARMs) are a class of drugs that selectively activate the androgen receptor in specific tissues, promoting muscle...

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Human penis size

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Yaman, Onder (2007). "Penile Length Changes in Men Treated with Androgen Suppression Plus Radiation Therapy for Local or Locally Advanced Prostate Cancer"...

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Cyproterone acetate

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appears to be due to marked suppression of total and free androgen levels as well as additional blockade of the androgen receptor. CPA has been found...

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Androgen receptor

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The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by binding...

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Anabolic steroid

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testosterone, the main male sex hormone, and produce effects by binding to the androgen receptor. Anabolic steroids have a number of medical uses, but are also...

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Trestolone

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also known as 7α-methyl-19-nortestosterone (MENT), is an experimental androgen/anabolic steroid (AAS) and progestogen medication which has been under...

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Gynecomastia

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breast tissue as a result of a hormone imbalance between estrogens and androgens. Gynecomastia can cause significant psychological distress or unease....

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Management of prostate cancer

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Loffredo M, Renshaw AA, DellaCroce A, Kantoff PW (2004). "6-month androgen suppression plus radiation therapy vs radiation therapy alone for patients with...

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Androgen replacement therapy

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Androgen replacement therapy (ART), often referred to as testosterone replacement therapy (TRT), is a form of hormone therapy in which androgens, often...

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Bladder cancer

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This hypothesis is also supported by the fact that men undergoing androgen suppression therapy for unrelated reason seem to have a lower risk of developing...

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Adrenal gland

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of metabolism and immune system suppression. The innermost layer of the cortex, the zona reticularis, produces androgens that are converted to fully functional...

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Mild androgen insensitivity syndrome

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Mild androgen insensitivity syndrome (MAIS) is a condition that results in a mild impairment of the cell's ability to respond to androgens. The degree...

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Partial androgen insensitivity syndrome

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Partial androgen insensitivity syndrome (PAIS) is a condition that results in the partial inability of the cell to respond to androgens. It is an X linked...

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Brachytherapy

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high-dose-rate brachytherapy (HDR-BT) boost with or without neoadjuvant androgen suppression for localized prostate cancer". International Journal of Radiation...

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Adrenal steroid

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glucocorticoids like cortisol and mineralocorticoids like aldosterone, adrenal androgens like dehydroepiandrosterone (DHEA), DHEA sulfate (DHEA-S), and androstenedione...

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Testosterone cypionate

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testosterone and suppression of the hypothalamic-pituitary-gonadal axis. Testosterone cypionate is a prodrug of testosterone and is an androgen and anabolic–androgenic...

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Trenbolone

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Trenbolone is an androgen and anabolic steroid (AAS) of the nandrolone group which itself was never marketed.[clarification needed] Trenbolone ester prodrugs...

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Pharmacokinetics of estradiol

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Abel P, et al. (May 2018). "Transdermal oestradiol as a method of androgen suppression for prostate cancer within the STAMPEDE trial platform". BJU International...

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Feminizing hormone therapy

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testosterone suppression is no longer needed. Antiandrogens are medications that prevent the effects of androgens in the body. Androgens, such as testosterone...

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Adrenal insufficiency

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(primarily cortisol), mineralocorticoids (primarily aldosterone), and androgens. These hormones are important in regulating blood pressure, electrolytes...

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Maximum androgen blockade

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receptor (AR) antagonism and inhibition or suppression of androgen production to attain maximal effectiveness in androgen deprivation therapy (ADT). An example...

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Clascoterone

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also under development in a higher concentration for the treatment of androgen-dependent scalp hair loss, under the brand name Breezula. The medication...

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Enobosarm

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MK-2866, and S-22, is a selective androgen receptor modulator (SARM) which is under development for the treatment of androgen receptor-positive breast cancer...

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