Maximum or maximal androgen blockade (MAB) or complete or combined androgen blockade (CAB) is a medical treatment involving the combination of both androgen receptor (AR) antagonism and inhibition or suppression of androgen production to attain maximal effectiveness in androgen deprivation therapy (ADT).[1] An example of MAB is the combination of bicalutamide, an AR antagonist, with a gonadotropin-releasing hormone (GnRH) analogue such as leuprorelin or cetrorelix.[1] MAB was developed for and is employed in the treatment of prostate cancer.[1]
Triple androgen blockade (TrAB) is a method of ADT in which a 5α-reductase inhibitor such as finasteride or dutasteride is added to CAB.[2][3]
MAB has been found to produce higher rates of gynecomastia (7 to 28%) than orchiectomy and GnRH analogues alone (1 to 16%), but lower rates than nonsteroidal antiandrogen monotherapy such as with bicalutamide (30 to 85%).[4]
^ abc"Maximum androgen blockade in advanced prostate cancer: an overview of the randomised trials". The Lancet. 355 (9214): 1491–1498. 2000. doi:10.1016/S0140-6736(00)02163-2. ISSN 0140-6736. S2CID 25366526.
^Hellerstedt, Beth A; Pienta, Kenneth J (2003). "The truth is out there: an overall perspective on androgen deprivation". Urologic Oncology: Seminars and Original Investigations. 21 (4): 272–281. doi:10.1016/S1078-1439(03)00046-2. ISSN 1078-1439. PMID 12954498.
^Leibowitz RL, Tucker SJ (2001). "Treatment of localized prostate cancer with intermittent triple androgen blockade: preliminary results in 110 consecutive patients". The Oncologist. 6 (2): 177–82. doi:10.1634/theoncologist.6-2-177. PMID 11306729.
^Di Lorenzo G, Autorino R, Perdonà S, De Placido S (December 2005). "Management of gynaecomastia in patients with prostate cancer: a systematic review". Lancet Oncol. 6 (12): 972–9. doi:10.1016/S1470-2045(05)70464-2. PMID 16321765.
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Maximum or maximal androgenblockade (MAB) or complete or combined androgenblockade (CAB) is a medical treatment involving the combination of both androgen...
this strategy is referred to as combined androgenblockade (also known as complete or maximal androgenblockade). Enzalutamide, apalutamide, and abiraterone...
Androgen deprivation therapy (ADT), also called androgen ablation therapy or androgen suppression therapy, is an antihormone therapy whose main use is...
in the United States Army Complete or Combined AndrogenBlockade (CAB), see Maximumandrogenblockade, medical treatment for prostate cancer Comprehensive...
H, Clarke M, Peto R, Schroder F, Dechering I, et al. (2000). "Maximumandrogenblockade in advanced prostate cancer: an overview of the randomised trials"...
Naylon EM, Whiting GW, Ernstoff MS, Ross SD (January 1997). "Maximumandrogenblockade in advanced prostate cancer: a meta-analysis of published randomized...
próstata avanzado" [Fatal interstitial lung disease associated with maximumandrogenblockade. Report of one case]. Revista médica de Chile (in Spanish). 144...
Dong EW, Naylon EM, Whiting GW, Ernstoff MS, Ross SD (1997). "Maximumandrogenblockade in advanced prostate cancer: a meta-analysis of published randomized...
Hill C, Iversen P, Shipley W, Soloway M, Sylvester R (2000). "Maximumandrogenblockade in advanced prostate cancer: an overview of the randomised trials"...
próstata avanzado" [Fatal interstitial lung disease associated with maximumandrogenblockade. Report of one case]. Revista médica de Chile (in Spanish). 144...
surgical orchiectomy or its continued use with a GnRH analogue (combined androgenblockade (CAB)). Adding antiandrogens to orchiectomy showed no benefit, while...
steroidogenesis. One side effect is hirsutism (in women) because of the excess androgen precursors created. The other commonly used agent for medical treatment...
in androgen steroidogenesis (e.g., CYP17A1). Although bicalutamide does not bind to the ERs, it can increase estrogen levels secondarily to blockade of...
"Activation of thymic regeneration in mice and humans following androgenblockade". Journal of Immunology. 175 (4): 2741–53. doi:10.4049/jimmunol.175...
effects of androgens like testosterone in the body, which it does by preventing them from interacting with their biological target, the androgen receptor...
(December 2005). "Six-week improvements in muscle mass and strength during androgen therapy in older men". The Journals of Gerontology. Series A, Biological...
saline excretion); it is mediated via proximal tubular adenosine receptor blockade. The acute increase in urinary output may increase the risk of dehydration...
classic endocrine hormones (primarily estrogens for breast cancer and androgens for prostate cancer) are now called hormonal therapies. By contrast, other...
2001). "Sodium-induced rise in blood pressure is suppressed by androgen receptor blockade". American Journal of Physiology. Heart and Circulatory Physiology...
The binding and activity of progesterone at the androgen receptor (AR), the biological target of androgens like testosterone and dihydrotestosterone (DHT)...
multicentric randomized trial". In Schröder FH (ed.). Proceedings Androgens and Anti-androgens, International Symposium, Utrecht, June 5th, 1982. Schering Nederland...
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