The Alzheimer type II astrocyte is thought to be a pathological type of cell in the brain; however, its exact pathology remains unknown. Like other astrocytes, it is a non-neuronal glial cell. It's mainly seen in diseases that cause increased levels of ammonia (hyperammonemia), such as chronic liver disease and Wilson's disease.[1]
They are not associated with Alzheimer's disease, but were first described by the same neuroscientist who first described the eponymous disease, Alois Alzheimer.[1]
^ abKumar, Vinay; Aster, Jon C; Perkins, James A; Cotran, Ramzi S; Abbas, Abul K; Turner, Jerrold R (2021). Robbins & Cotran pathologic basis of disease (Tenth ed.). Philadelphia, Pa.: Elsevier. p. 1243. ISBN 978-0323531139.
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The AlzheimertypeIIastrocyte is thought to be a pathological type of cell in the brain; however, its exact pathology remains unknown. Like other astrocytes...
of all glia. Another study reports that astrocytes are the most numerous cell type in the brain. Astrocytes are the major source of cholesterol in the...
accomplished by a stimulation of accessory brain cells called astrocytes. Hypothalamic astrocytes that produce Fatty Acid Binding Protein 7 (FABP7) are targets...
lipopolysaccharide on astrocytes. The diagnosis of hepatic encephalopathy can only be made in the presence of confirmed liver disease (types A and C) or a portosystemic...
formation of Rosenthal fibers—abnormal clumps of protein that accumulate in astrocytes in the brain. The disease occurs in both males and females, and no ethnic...
component of the amyloid plaques found in the brains of people with Alzheimer's disease. The peptides derive from the amyloid-beta precursor protein...
at very low levels in CNS astrocytes and oligodendrocytes. Pathologies and dementias of the nervous system such as Alzheimer's disease and Parkinson's disease...
infection or injury. Various cell types in the brain may produce cytokines and chemokines such as microglia, astrocytes, endothelial cells, and other glial...
scientist Santiago Ramón y Cajal defined a "third element" (cell type) besides neurons and astrocytes. Pío del Río Hortega, a student of Santiago Ramón y Cajal...
"Involvement of TLR4/Type I IL-1 Receptor Signaling in the Induction of Inflammatory Mediators and Cell Death Induced by Ethanol in Cultured Astrocytes". The Journal...
leads to increased Chi3l1 expression in astrocytes. There is evidence that YKL-40 levels are elevated in Alzheimer's patients compared to cognitively normal...
deviations in normal nervous function. Various cell types play a role in HR, including astrocytes, smooth muscle cells, endothelial cells of blood vessels...
and other types of diseases, including Alzheimer disease, Down syndrome, epilepsy, amyotrophic lateral sclerosis, schwannoma, melanoma, and type I diabetes...
synaptic pruning, a process of shaping neuronal circuitry by microglia- and astrocyte-mediated removal of excessive synapses via phagocytosis. In brain, the...
Metadherin, also known as protein LYRIC or astrocyte elevated gene-1 protein (AEG-1) is a protein that in humans is encoded by the MTDH gene. MTDH (AEG-1)...
administered to the United States military, showed increased reactive astrocytes, increased apoptosis of motor neurons and microglial proliferation within...
brain. It is formed by the tight junctions between endothelial cells, astrocytes, and pericytes in the capillaries. The BBB has high electrical resistance...
There are many activated microglia over-expressing IL-1 in the brains of Alzheimer patients that are distributed with both Aβ plaques and neurofibrillary...
on an axon and the postsynaptic part is located on a dendrite or soma. Astrocytes also exchange information with the synaptic neurons, responding to synaptic...
evoked or induced power. Sloan SA, Barres BA (August 2014). "Mechanisms of astrocyte development and their contributions to neurodevelopmental disorders"....
in turn allows for molecules to leak into the CNS. This then activates astrocytes and microglia, causing an immune response within the brain. Neuroinflammation...