Congenital adrenal hyperplasia, Addison's disease, and Secondary adrenal insufficiency.[1]
Treatment
Glucocorticoids.[2]
Adrenocorticotropic hormone deficiency is a rare disorder characterized by secondary adrenal insufficiency with minimal or no cortisol production and normal pituitary hormone secretion apart from ACTH.[3] ACTH deficiency may be congenital or acquired, and its symptoms are clinically similar to those of glucocorticoid deficiency. Symptoms consist of weight loss, diminished appetite, muscle weakness, nausea, vomiting, and hypotension. Low blood sugar and hyponatremia are possible; however, blood potassium levels typically remain normal because affected patients are deficient in glucocorticoids rather than mineralocorticoids because of their intact renin-angiotensin-aldosterone system. ACTH may be undetectable in blood tests, and cortisol is abnormally low.[1] Glucocorticoid replacement therapy is required. With the exception of stressful situations, some patients with mild or nearly asymptomatic disease may not require glucocorticoid replacement therapy.[2] As of 2008 about two hundred cases have been described in the literature.[5]
^ abc"Symptoms, Causes, Treatment". National Organization for Rare Disorders. February 11, 2015. Retrieved November 11, 2023.
^ abcdAndrioli, Massimiliano; Giraldi, Francesca Pecori; Cavagnini, Francesco (October 30, 2006). "Isolated corticotrophin deficiency". Pituitary. 9 (4). Springer Science and Business Media LLC: 289–295. doi:10.1007/s11102-006-0408-5. ISSN 1386-341X. PMID 17077949. S2CID 12553579. Retrieved November 10, 2023.
^ abKamoun, Mahdi; Kacem, FatenHadj; Charfi, Nadia; Mnif, MounaFeki; Akid, Faouzi; Mnif, Fatma; Naceur, BasmaBen; Rekik, Nabila; Mnif, Zainab; Abid, Mohamed (2013). "Isolated adrenocorticotropic hormone deficiency due to probable lymphocytic hypophysitis in a woman". Indian Journal of Endocrinology and Metabolism. 17 (7). Medknow: S107–S110. doi:10.4103/2230-8210.119521. ISSN 2230-8210. PMC 3830271. PMID 24251125.
^Cite error: The named reference LK 2003 p. was invoked but never defined (see the help page).
^Syriou, Vassiliki; Moisidis, Anestis; Tamouridis, Nikolaos; Alexandraki, Krystallenia; Anapliotou, Margarita (October 15, 2008). "Isolated adrenocorticotropin deficiency and flexion contractures syndrome". Hormones. 7 (4). Springer Science and Business Media LLC: 320–324. doi:10.14310/horm.2002.1213. ISSN 1109-3099. PMID 19121993. Retrieved November 11, 2023.
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