positive regulation of insulin receptor signaling pathway
positive regulation of receptor signaling pathway via JAK-STAT
negative regulation of epithelial to mesenchymal transition
negative regulation of receptor signaling pathway via JAK-STAT
negative regulation of epithelial cell migration
negative regulation of NIK/NF-kappaB signaling
G protein-coupled receptor signaling pathway
regulation of fatty acid biosynthetic process
positive regulation of cold-induced thermogenesis
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
51094
72674
Ensembl
ENSG00000159346
ENSMUSG00000026457
UniProt
Q96A54
Q91VH1
RefSeq (mRNA)
NM_001290553 NM_001290557 NM_001290629 NM_015999
NM_028320 NM_001306069
RefSeq (protein)
NP_001277482 NP_001277486 NP_001277558 NP_057083
NP_001292998 NP_082596
Location (UCSC)
Chr 1: 202.94 – 202.96 Mb
Chr 1: 134.34 – 134.36 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Adiponectin receptor 1 (AdipoR1) is a protein which in humans is encoded by the ADIPOR1 gene.[5] It is a member of the progestin and adipoQ receptor (PAQR) family, and is also known as PAQR1.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000159346 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000026457 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T (June 2003). "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects". Nature. 423 (6941): 762–9. Bibcode:2003Natur.423..762Y. doi:10.1038/nature01705. PMID 12802337. S2CID 52860797.
^Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, Funk WD (September 2005). "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif". Journal of Molecular Evolution. 61 (3): 372–80. Bibcode:2005JMolE..61..372T. doi:10.1007/s00239-004-0375-2. PMID 16044242. S2CID 31473802.
and 25 Related for: Adiponectin receptor 1 information
Adiponectinreceptor1 (AdipoR1) is a protein which in humans is encoded by the ADIPOR1 gene. It is a member of the progestin and adipoQ receptor (PAQR)...
G protein-coupled receptors, and one receptor similar to the cadherin family: Adiponectinreceptor1 (AdipoR1) Adiponectinreceptor 2 (AdipoR2) T-cadherin...
Adiponectinreceptor 2 (AdipoR2) is a protein which in humans is encoded by the ADIPOR2 gene. It is a member of the progestin and adipoQ receptor (PAQR)...
small-molecule agonist of the adiponectinreceptor1 (AdipoR1) and adiponectinreceptor 2 (AdipoR2) (Kd = 1.8 μM and 3.1 μM, respectively). It activates...
[citation needed] They have been found to act as agonists of the adiponectinreceptor1. Arvind Saklani; Manas Ranjan Sahoo; Prabhu Dutt Mishra; Ram Vishwakarma...
grass genus). Gramine has been found to act as an agonist of the adiponectinreceptor1 (AdipoR1). The LD50 of gramine is 44.6 mg/ kg iv in mice and 62...
Japanese encephalitis. It has been found to act as an agonist of adiponectinreceptor1 (AdipoR1). Hayashi, K.; Narutaki, K.; Nagaoka, Y.; Hayashi, T.;...
Ahsan, H; Pasche, B; Mantzoros, C (2008). "Variants of the Adiponectin and AdiponectinReceptor1 Genes and Breast Cancer Risk". Cancer Research. 68 (9):...
is the μ-opioid receptor (MOR), which is bound and activated by the opioid peptide hormone β-endorphin. Agonists Peptide Adiponectin ADP-355 ADP-399 Non-peptide...
leading to visual degeneration and blindness. They discovered that adiponectinreceptor1 (AdipoR1) is a regulator of these RPE cell functions and demonstrated...
insulin secretion. Tirzepatide has been reported to increase levels of adiponectin, an adipokine involved in the regulation of both glucose and lipid metabolism...
inconclusive. Matairesinol has been found to act as an agonist of the adiponectinreceptor1 (AdipoR1). Matairesinol at Sigma-Aldrich Seibel, Wilfried; Kim Chung...
Forny-Germano L, De Felice FG, Vieira MN (2019). "The Role of Leptin and Adiponectin in Obesity-Associated Cognitive Decline and Alzheimer's Disease". Frontiers...
Kihara, Shinji; Walsh, Kenneth (1 February 2007). "Adiponectin modulates inflammatory reactions via calreticulin receptor–dependent clearance of early apoptotic...
genetics that boost adiponectin, and they have higher circulating adiponectin, suggesting a link between longevity and adiponectin production. In addition...
binding to specific receptor proteins in the target cell, resulting in a change in cell function. When a hormone binds to the receptor, it results in the...
of chemerin or its receptor, CMKLR1 impairs differentiation into adipocytes, and reduces the expression of GLUT4 and adiponectin, while increasing expression...
J (July 2004). "Alterations in the dynamics of circulating ghrelin, adiponectin, and leptin in human obesity". Proceedings of the National Academy of...
hormones when released into the blood. When a peptide hormone binds to a receptor on the surface of the cell, a second messenger appears in the cytoplasm...
receptor is a seven-membrane-spanning G protein-coupled receptor. Upon ligand binding, the receptor undergoes conformation changes that stimulate the enzyme...
25-dihydroxycholecalciferol. It is a hormone which binds to and activates the vitamin D receptor in the nucleus of the cell, which then increases the expression of many...
Global Information
